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Locked-sugar oligonucleotides with high affinity, specificity, and nuclease resistance for demanding assays.
Bridged Nucleic Acids (BNAs) are RNA/DNA analogs in which the ribose sugar is “locked” by a covalent bridge (typically between the 2′-O and 4′-C). This rigidifies the sugar into a C3′-endo conformation that promotes exceptionally stable duplex formation with complementary DNA or RNA.
Bio-Synthesis provides end-to-end custom BNA oligonucleotide synthesis—from sequence design through labeling and conjugation—delivered with comprehensive QC documentation.
Higher Tm versus DNA/RNA of the same length enables shorter probes with stronger binding.
Improved single-base mismatch discrimination for SNP and mutation targeting.
Locked sugars increase resistance to nuclease degradation and harsh conditions.
Standard labeled BNA: 2–3 weeks from order confirmation. Complex mixmers or multi-label probes may require additional time.
Lead time is sequence- and modification-dependent; rush options may be available.
Panels or RFPs welcome—attach details in the form.
What is BNA? Bridged Nucleic Acids (BNAs) are nucleic-acid analogs in which the ribose is “locked” by a covalent bridge (typically 2′-O to 4′-C). This conformational lock enforces a C3′-endo sugar pucker, pre-organizing the backbone for A-form–like duplexes and yielding markedly higher affinity and specificity to complementary DNA or RNA.
Note: Extremely high BNA content can elevate Tm beyond desired windows and reduce solubility. We can optimize the BNA pattern for your assay.
Most probes use 12–20-mers. Shorter designs are feasible thanks to the higher Tm of BNA mixmers.
Yes—mixmers (BNA with DNA/RNA) allow fine control of Tm, affinity, and specificity.
Yes. The locked conformation typically increases single-base discrimination compared to DNA probes.
We support RUO through cGMP with appropriate QA oversight. Include your regulatory needs in the request.
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