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Design, SELEX selection, chemical modification, and conjugation — end-to-end support from research to GMP.
Aptamers are short, single-stranded DNA or RNA molecules that fold into defined 3D structures to bind targets with high affinity and specificity — including proteins, small molecules, ions, and whole cells.
Bio-Synthesis provides custom aptamer solutions: from design and SELEX selection through chemical modification, labeling, conjugation, purification, and comprehensive QC.
Need unusual chemistries or dual-function constructs? Share your schematic—we’ll review feasibility and route.
Custom synthesis of known aptamer sequences: 1–2 weeks. Full SELEX campaigns vary (4–10+ weeks) based on target complexity and screening depth.
Timelines depend on target type, modifications, and verification assays. Rush options may be available.
NDA-friendly consultations available. Include any IP constraints or literature references.
SELEX Overview: Aptamers are discovered via SELEX (Systematic Evolution of Ligands by EXponential enrichment), which iteratively enriches high-affinity binders from libraries (1013–1015 variants). Counter-selection removes off-target binders; winners are cloned and sequenced to identify lead candidates.
Need therapeutic profiling (PK/PD, serum stability, toxicity)? We can integrate study-ready chemistries and documentation.
We do both. Provide a literature sequence for direct synthesis, or engage our SELEX service to discover new binders to your target.
We combine 2′-F/2′-OMe/LNA/BNA, terminal capping, and PEGylation or lipids to enhance nuclease resistance and pharmacokinetics.
Affinity depends on target complexity. Many projects reach low-nM to sub-nM Kd after optimization.
Yes. We support RUO through cGMP with appropriate QA oversight and documentation.
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