LNP Encapsulation Services
Bio-Synthesis, a US based Company has the capacity to use advanced Microfluidics technology for the precise and reproducible development of LNP-based drug delivery systems for pharmaceutical and research applications.
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Comprehensive mRNA-LNP Production – From mRNA synthesis to LNP formulation, manufacturing, and fill & finish
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Custom Encapsulation – Formulation of siRNA, mRNA, plasmid DNA, peptides, or proteins into LNPs for efficient delivery
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Scalable & Reproducible Manufacturing – Production from milligram to gram scale, ensuring batch-to-batch consistency with optimized processes
Our expertise allows for tailored LNP optimization based on your specific payload and application needs.
Overview of LNP
What are lipid nanoparticles ( LNPs)?
LNPsare “lipid nanoparticles”, which are delivery systems that carries drugs and other therapeutic molecules to specific parts of cells or tissue in the human body.LNPs are made of lipids that surround a hydrophobic core, which contain drugs, peptides, or nucleic acids (DNA, RNA, siRNA, mRNA, miRNA, etc.).
Lipid nanoparticles (LNPs) are tiny, spherical molecular carriers ranging in diameter from 1 to 100 nanometers and are widely used for drug and gene delivery, including RNA, DNA, and drugs, but recently, particularly for mRNA vaccines and therapeutics. Compared to traditional delivery methods, because of their improved stability and cellular uptake of nucleic acids, LNPs are now preferred for vaccines.
How is it used?
LNPs can deliver drugs that are difficult to get into the body, such as hydrophobic or negatively charged drugs.
Why are LNPs important?
- LNPs improve the stability and bioavailability of drugs.
- LNPs can target specific sites in the body.
- LNPs have been successful in delivering drugs and vaccines.
Formulation typically consists of four main lipid type, read more:
- Lonizable Lipids
- Phospholipids
- Cholesterol
- PEGylated Lipids
Typical applications for “Lipid Nanoparticles (LNPs) for the Delivery of Modern Therapeutic Drugs” are:
Cancer Therapy: LNPs allow the targeted delivery of chemotherapeutic drugs to tumor cells.
Diagnostics: LNPs can carry imaging agents for disease detection.
Gene Therapy: LNPs enable the delivery of siRNA, mRNA, or CRISPR components for treating genetic disorders.
Vaccines: Modern mRNA vaccines utilize LNPs, such as vaccines for COVID-19 (Pfizer-BioNTech and Moderna).
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