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Custom Morpholinos

US‑Based Manufacturing

Custom Morpholino Synthesis

High-quality Morpholino (PMO) oligos for gene silencing, splice modulation, and targeted delivery—designed and synthesized to your exact specifications.

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Fast Turnaround Comprehensive QC Confidential & Secure

What are Morpholinos?

Morpholino phosphorodiamidates (PMOs) are charge-neutral antisense analogs that bind complementary mRNA to block translation or modulate splicing. Their neutral backbone yields excellent biostability and low nonspecific binding.

  • Applications: functional genomics, exon skipping, validation studies, targeted delivery.
  • Benefits: high specificity, robust stability, low off-target interactions.

Benefits

Precise Targeting

Custom sequences designed against your gene of interest to maximize on-target efficacy and minimize off-target effects.

Enhanced Performance

Optional modifications to improve stability, uptake, and bioavailability for in vitro or in vivo use.

Rapid Delivery

Accelerated synthesis timelines and responsive support to keep your program moving.

Our Capabilities

Synthesis & Scales

  • Any sequence or length (typical 20–30-mer; longer upon request)
  • Flexible scales from research to large batches
  • Sequence design support and in‑silico specificity checks

Quality Control

  • Mass confirmation and purity assessment
  • Optional sterility/endotoxin tests
  • Certificate of Analysis (CoA) available

Popular Modifications & Services

Category Examples Use Cases
Delivery Enhancements Cell-penetrating peptides (CPPs), lipid conjugates, GalNAc, PEG Improve cellular uptake, liver targeting, and circulation time
Targeting & Tracking Biotin, fluorophores (FAM, Cy dyes), quenchers Pull‑down assays, imaging, FRET studies
Formulation Lyophilization, custom buffers, concentration normalization Ready‑to‑use formats for screening or in vivo
Documentation Sequence records, CoA, custom reports Traceability and regulatory support

How It Works

1) Share Your Target

Provide the gene, transcript ID, desired exon/intron region, and any constraints (length, GC, delivery).

2) Design & Quote

We review, propose sequences and modifications, and return a transparent quote and timeline.

3) Synthesis & QC

Manufacture, purify, and QC per specification; deliver with documentation and support.

Why Choose Bio‑Synthesis?

Customization for Targeted Gene Modulation

Design for gene silencing, splice correction, or expression regulation. Every project is tailored to your goals.

Expert Team

Experienced molecular biologists ensure accurate design, synthesis, and troubleshooting support.

Advanced Technologies

State‑of‑the‑art platforms deliver high specificity, stability, and reduced off‑target interactions.

Confidential & Secure

Strict data protection and confidentiality at every step of the engagement.

FAQs

What length should I choose?

Typical Morpholinos are 20–30 nucleotides. Longer or shorter designs are available depending on the target region and application.

Do you support splice-modulating designs?

Yes. Provide your exon/intron boundaries and intended exon skipping/inclusion outcome; we will propose designs and controls.

Can you help with delivery?

We offer peptide, lipid, PEG, and GalNAc options and can advise on in vitro vs. in vivo delivery strategies.

Ready to start your Morpholino project?

Get a fast, personalized quote—include your gene target, desired length, and any modifications.

Request a Quote

Reference

Have a key paper to cite? Add it here: Reference article link.

Speak to a Scientist

Email: info@biosyn.com  |  Phone: +1 (800) 227‑0627