Advanced Peptide Architecture Services
Branched, multivalent, and cysteine-controlled peptide architectures for advanced research.
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Bio-Synthesis provides multivalent and architecture-controlled peptide synthesis services including branched peptides, multiple antigen peptides (MAPs), multivalent peptide constructs, and cysteine-selective designs. These architecture-controlled peptides are synthesized to a defined topology (number of arms, branching points, valency, and reactive handles) rather than a single linear chain. This enables higher functional density and predictable display—useful for antibody production, epitope mapping, receptor binding, multivalent inhibitors, and conjugation workflows.
Best-fit when you need
Exact arms/branching and placement of epitopes or motifs.
Predictable handles for labeling or controlled attachment.
Multivalent engagement for stronger apparent affinity.
Use this table to map your project to the right architecture. For detailed options, see the service sections below.
Related service pages (internal links)
For full options, pricing drivers, and examples, visit the dedicated service pages:
Branched peptides introduce one or more branching points so multiple peptide arms extend from a central node. This increases functional density and enables multi-epitope or multi-motif display with controlled geometry.
Related: Branched Peptide Synthesis service page.
MAPs are multiepitope constructs commonly used to increase antigen density without carrier proteins. They are frequently selected for antibody production and vaccine research where repeated epitope display matters.
Related: MAPs service page.
Multivalent peptides present repeated motifs with defined spacing and orientation to improve functional binding. Compared with simply mixing monomers, a single multivalent construct can deliver stronger apparent affinity and improved assay performance.
Related: Multivalent peptide service page.
Cysteine-selective design uses strategic cysteine placement and protection strategies to enable controlled thiol chemistry—useful for site-specific labeling, controlled conjugation, and defined disulfide states.
Related: Cysteine-selective design service page.
Branched peptide synthesis is a broad family of multi-arm architectures. MAP peptide synthesis is a commonly used immunogen-style dendrimer format designed to increase antigen (epitope) density without carrier proteins.
Valency is project-dependent. Common designs range from 2–8 arms, with spacing/linkers tuned for accessibility and binding. Provide your target application and we’ll recommend a practical topology.
Send the motif/sequence(s), desired copy number (2×/3×/4×), linker preferences (length/rigidity), target purity/scale, and any required handle (cysteine, click, biotin, dyes). If you know receptor spacing or assay format, include it.
Use cysteine-selective peptide synthesis when thiol chemistry (e.g., maleimide) is compatible and you want a simple, efficient site-specific conjugation. Consider click handles when you need higher orthogonality, reduced thiol side reactions, or multiplexed conjugations.
Yes. Specify whether you need reduced material (free thiols for conjugation) or oxidized material (defined disulfides). For multiple cysteines, we can plan protection/oxidation strategies to control the final thiol state.
Standard deliverables typically include LC–MS and purity reporting. For complex architectures, additional characterization (e.g., mapping or confirmation of thiol/disulfide state) can be added to support reproducibility and downstream conjugation.
Share your sequence(s), desired topology (arms/copies/spacing), required handles (cysteine/click/labels), and the intended application. We’ll recommend practical specifications and a synthesis/QC plan aligned to your goals.
Tip: If the peptide is hydrophobic/long/cysteine-rich, include that context so we can route the request to the right synthesis strategy.
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