Find the right chemistry—by property or function.
Scan the landscape of modification types and quickly jump to what you need—probe chemistries, hybridization control, nuclease stability, intercalators, universal bases, metal chelates, redox labels, and more. All options are available with expert design support, scalable manufacturing, and full QC.
Structured DNA/RNA ligands for SELEX-ready libraries with high-affinity binding to proteins, cells, or small molecules; ideal for capture, imaging, and therapeutics.
Biotin/streptavidin capture, Dig/DNP detection, His-tag style NTA-Ni binding for pull-down, detection, or immobilization in ELISA, lateral flow, and biosensor.
Environment-sensitive bases and dark reporters for label-free detection, hybridization monitoring, or FRET acceptors without emission.
Photocleavable or chemically cleavable dye linkers for background suppression, release assays, and spatiotemporal activation.
G-quadruplex, triplex-forming, and structural stabilizers to control folding, topology, and higher-order organization. Supports aptamer stability and nanostructure design.
Protected, reactive bases that are transformed post-synthesis to introduce custom functional groups at defined positions for bioconjugation.
Isotopically labeled nucleotides (²H) for mechanistic studies, mass-spectrometric tracing, and pharmacokinetic profiling.
Reversible photochromic units (e.g., azobenzene) to modulate Tm or hybridization singal, conformation. Supports photo-gating and logic circuits.
Wobble/ambiguous bases (e.g., inosine, mixed bases) to accommodate variability in target sequences and library design. Balance degeneracy with specificity using modeling support.
LNA/BNA/cEt, MOE and related chemistries to tune Tm, mismatch discrimination, and clamping for PCR/ASO/antisense. Backbones: PS, PM, PN to increase stability and binding half-life.
Planar aromatic intercalators (psoralen, acridines, naphthalimides, YO/YOYO) for crosslinking, stabilization, and imaging.
EDTA/DTPA/NTA and custom chelators for radiometals, lanthanides, or catalytic cleavage mapping. Lanthanide/ radiometal labeling for TR-FRET or SPECT/PET tracers.
Backbone and sugar chemistries (PS, PM/PN, 2′-OMe, 2′-F, LNA/BNA, cEt) and terminal caps to enhance in vitro/in vivo durability. Sugar variants (2′-OMe, 2′-F, LNA/BNA, cEt, UNA) for ASO/siRNA.
NOMP-dT, DEACM cages for light-triggered activation, cleavage, or release. Ideal for spatiotemporal control in cells or materials.
Indole/5-nitroindole and related analogs that pair non-specifically to enable mixed templates or degenerate priming. Useful in degenerate primers and mixed templates.
Tell us your assay, instrument, scale, and QC needs. We’ll propose the optimal base, backbone, or label with delivery timeline and quote.
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