Custom oligonucleotide process development is far more than linking bases —
it’s a multi-step R&D and manufacturing pipeline that must balance
chemistry, scalability, purity, and compliance, especially for therapeutic and diagnostic use.
At Bio-Synthesis, Inc., we deliver end-to-end solutions, transforming concepts into scalable,
reproducible, and regulatory-ready processes. Our expertise covers
DNA, RNA, LNA, PNA, Morpholino, and mixed-backbone chemistries, with decades of experience in
integrating complex modifications,
conjugates, and novel chemistries into robust workflows.
We guide projects from design and feasibility through
pilot synthesis, purification optimization, scale-up,
analytical validation, and formulation — all within a rigorous quality framework.
Whether your goal is research-use, ISO13485, or
GLP-compliant production, every step is
data-driven and quality-controlled.
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Complex and highly modified oligos, including rare/custom monomers
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Integrated analytical capabilities: HPLC, LC-MS, CE, UV, stability studies
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Flexible scale — from µmol R&D batches to multi-gram GMP lots
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Full documentation and tech transfer for regulatory filings