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Multi-arm architectures for multivalent targeting, signal amplification, and multiplex hybridization—engineered to your specifications.
Branched oligonucleotides incorporate two or more branches extending from a central scaffold or internal branch point, enabling multiple functional groups, labels, or sequence domains on a single molecule. This unlocks high-density signaling, multivalent binding, and true multiplex capability in compact designs.
Bio-Synthesis delivers end-to-end custom branched oligo synthesis—from collaborative design and arm layout to labeling, conjugation, purification, and documentation.
Present identical or orthogonal binding domains to boost avidity and target capture.
Carry multiple dyes/labels on one scaffold to raise signal without increasing probe count.
Combine distinct sequences on separate arms for simultaneous hybridization events.
We can integrate LNA/BNA segments for higher Tm and mismatch discrimination, or PS backbones for stability in complex matrices.
Need unusual linkers or orthogonal chemistry? Send your schematic—we’ll review feasibility and route.
Standard branched constructs: 2–3 weeks after order confirmation. Complex multi-arm/multi-label designs may require additional time.
Lead time depends on architecture, labels, and purification. Rush options may be available.
RFPs welcome—attach diagrams or prior designs for fastest scoping.
What are Branched Oligonucleotides? Branched oligonucleotides are synthetic nucleic acid constructs in which two or more arms extend from a central branch point or scaffold. These arms may carry identical or different sequences, labels, or ligands, enabling multifunctional capability in a single molecule.
We can optimize branch architecture, arm composition, and label placement to achieve the best balance of stability, specificity, and performance for your assay.
Match arm count to your function: two arms for bivalency or dual-label; three for multiplex detection; four for maximum signal or multi-epitope capture. Dendrimers amplify density when ultra-high payloads are needed.
Yes. Mixmers help tune Tm, specificity, and stability. We can recommend %LNA/BNA by region to hit assay windows.
We add PEG/AEEA spacers or longer linkers to improve solubility and minimize quenching/sterics for multi-dye constructs.
We support RUO through cGMP with appropriate QA oversight. Include your regulatory needs in the request for scoping.
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