Unlock the full potential of your oligonucleotides with application-specific modifications. Whether you're designing probes for diagnostics, developing RNA therapeutics, or engineering gene regulators, selecting the right modification is key to maximizing efficiency, stability, and impact.
BSI remains committed to delivering high-quality, custom-modified oligonucleotides backed by expert technical support. Explore our diverse and continuously growing portfolio of over 3000 oligo modifications, designed to meet your application’s exact demands
If the modification you need is not listed, please don’t hesitate to contact us—our team is ready to assist with custom solutions tailored to your specific requirements.
Custom antisense gapmers designed to silence target RNA via RNase H, combining nuclease resistance with potent gene knockdown.
ExploreChemically modified siRNA duplexes optimized for stability, delivery, and efficient RNA interference.
ExploreConjugation strategies (GalNAc, cholesterol, fatty acids, peptides, PEG) that guide oligonucleotides to specific cells and tissues.
ExploreAntibody–oligonucleotide conjugates for targeted delivery and combined therapeutic or diagnostic applications.
ExploreModified oligos to study or modulate DNA methylation, histone interactions, and chromatin remodeling.
ExploreUse of CPPs, lipids, vitamins, and hydrophobic moieties to enhance cellular uptake and endosomal escape.
ExploreOligos that modulate repair pathways, correct mutations, or act as templates for homology-directed repair.
ExploreCrosslinking bases and reactive handles to create covalent DNA–DNA or DNA–protein linkages for structural biology studies.
ExploreModified bases that probe mutagenesis, introduce site-specific changes, or analyze methylation-dependent processes.
ExploreReactive modifications enabling enzyme-free ligation and assembly using click chemistry or other orthogonal chemistries.
ExploreLabels and chemistries that produce visible signals for rapid, low-cost detection in assays and diagnostics.
ExploreTermini blockers and spacers that prevent unwanted extension or ligation in molecular biology workflows.
ExploreRedox-, enzyme-, pH-, or photo-cleavable linkers for controlled oligo release in cells or therapeutic settings.
ExploreModified oligos used to explore sequence–function relationships, structural dynamics, and activity profiles.
ExploreClick-compatible handles for labeling, imaging, and capture without perturbing native biology.
ExploreModified nucleotides that terminate polymerase extension—used in sequencing, mutagenesis, and drug studies.
ExplorePhotocaged oligos carrying light-sensitive groups for spatiotemporal control of gene expression or probe activation.
ExploreRedox oligos (MB, Fc) for electrochemical sensing—high S/N DPV/SWV, stable linkers, gold/SP electrodes.
ExploreOur scientists can recommend modification patterns and conjugates aligned to your target, route, and assay.
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