Reversible, light‑controlled moieties—azobenzene (incl. visible‑light variants), arylazopyrazole, diazocine, diarylethene, and spiropyran—to modulate hybridization, structure, and capture/release on demand.
Photoswitchable markers reversibly change conformation/absorption when illuminated, enabling optical control of hybridization, conformation, quenching, or capture. In oligonucleotides, azobenzene and related families can stabilize/destabilize duplexes in one state and reverse under another wavelength or via thermal relaxation—ideal for photo‑gated hybridization, switchable toeholds, aptamer capture/release, and molecular logic.
Trans often stabilizes; cis bends/destabilizes. 1–3 units tune Tm shift.
Red‑shift into visible; improves biocompatibility and penetration.
High‑contrast (AZP) or inverted stability (diazocine) for extended states or dark‑favored designs.
Bistable open/closed; excellent fatigue—great for many cycles.
SP↔MC switching couples optical contrast with environment sensitivity.
Internal base replacements or pendant/backbone linkers; multiple units amplify effects.
Toggle duplex formation or strand displacement with light.
Control binding and elution via light—no chaotropes or heat.
DTE/AZP support bistability and high cycle counts for logic/memory.
Choose photoswitch family (Azo/AZP/DTE/SP/Diazocine/HTI), placement (internal/base vs linker), and wavelengths/filters.
Synthesis with selected unit(s) → Purification (Desalt→HPLC/UPLC) → LC‑MS identity → Optional spectra & switching/fatigue tests.
Confirm λ/filters and cycle count; set visible/UV exposure as needed; finalize buffer and crosstalk/FRET checks.
Share sequence, wavelengths, placement, and cycle count—We’ll return a tuned design and QC plan.
By submitting, you agree to be contacted regarding your request.
On request, we’ll align literature‑style switching conditions and placements to your instrument.
Trusted by biotech leaders worldwide for over 45+ years of delivering high quality, fast and scalable synthetic biology solutions.