Yes. We can work with customer-supplied antibodies and other proteins, provided they are supplied in labeling-compatible buffers. If needed, we can advise on purification or buffer exchange before conjugation.
High-quality starting material is critical for antibody–oligo conjugates. Buffers and stabilizers can interfere with labeling and should be removed prior to conjugation. Bio-Synthesis can review formulations and recommend purification or buffer exchange.
Please submit your antibody in one of the following formats:
- 2 mg/mL in 0.05 M PBS, pH 7.2–7.4, containing 0.15 M NaCl; no additives; sterile filtered; ship overnight on ice packs (no dry ice).
- 2 mg/mL in 0.05 M PBS, pH 7.2–7.4, containing 0.15 M NaCl and 50% glycerol; no other additives; ship overnight on ice packs or dry ice. Note: The antibody will require purification prior to labeling.
The antibody must be in an amine-free buffer (e.g., no Tris) and free of additives that may interfere with labeling (e.g., azide, gelatin). If you’re unsure, our technical team can advise on individual formulations.