Add **bioactive small molecules** to DNA/RNA—puromycin, doxorubicin, cisplatin, folate, methotrexate, tocopherol, ferrocene, TEMPO, anthraquinone, psoralen—for **display, delivery, sensing, and crosslinking**. Product & notes panels include nested Technical Notes.
Small-Molecule Functional Tags expand oligonucleotide utility beyond dyes and peptides. We custom-conjugate puromycin, doxorubicin, cisplatin, folate, methotrexate, tocopherol, ferrocene, TEMPO, anthraquinone, psoralen and more to DNA/RNA for **mRNA display**, **oligo–drug conjugates**, **targeted delivery**, **electrochemical sensing**, and **UV crosslinking**.
Bio-Synthesis provides design support (linker selection, placement), scalable synthesis (nmol→gram), and ISO-aligned QC (HPLC, ESI-MS; optional CE/SEC & functional tests). See also: Spacer & Linker • Oligo Bioconjugation • Quencher Compatibility.
Custom linkers & ligands (DBCO/TCO, NHS, thiol, aldehyde) with full QC.
C2–C12, HEG/PEG, PC photocleavable, abasic; geometry control.
Ferrocene/AQ sensors, dye/quencher probes, beacon design.
Low-MW ligands added to DNA/RNA to impart bioactivity or readouts—e.g., puromycin for peptide–RNA fusion, doxorubicin/cisplatin for drug conjugates, ferrocene for electrochemistry, psoralen for crosslinking.
Puromycin conjugates enable mRNA display/RaPID by covalently linking the nascent peptide to its encoding RNA for library selections and discovery.
Oligo–drug conjugates combine sequence specificity with chemotherapeutic potency for targeted delivery and mechanistic studies.
They provide electrochemical readouts for hybridization, aptamer binding, and conformational switching in biosensors.
Yes—e.g., folate for receptor targeting, tocopherol to enhance uptake/serum binding, and hormone ligands for receptor-mediated delivery.
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