High-sensitivity, PCR‑free signal amplification for RNA/DNA detection in QuantiGene, ViewRNA, MERFISH, and FISH. Custom design, scalable synthesis, and ISO‑aligned QC.
bDNA amplifier probes (branched DNA) deliver robust, enzyme‑free signal gain by layering pre‑amplifiers, amplifiers, and labeled probes onto a captured target. Unlike PCR—which amplifies the target—bDNA systems amplify the signal, enabling sensitive detection in cells, tissues, or plate‑based assays with low background.
Layered hybridization: target capture → pre‑amplifier docking → multiple amplifiers → multiple labeled probes per amplifier.
A hybridization probe system that amplifies signal using branched DNA pre‑amplifiers and amplifiers, rather than amplifying the target itself (PCR).
PCR amplifies the target; bDNA amplifies the detection signal via layered hybridization. No polymerase is required, which reduces background and preserves spatial context in situ.
Yes. We support disulfide‑linked dyes and other cleavable strategies for MERFISH/smFISH cycles.
Typical designs use 1 pre‑amplifier per target, 3–5 amplifiers per pre‑amplifier, and 2–4 labels per amplifier; we tune this for your SNR, kinetics, and imaging constraints.
Yes. We offer ISO‑aligned documentation and phased technical transfers for clinical‑adjacent programs.
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