GalNAc for liver targeting, lipid & vitamin conjugates for CNS delivery, peptide & ligand strategies for oncology and immune cell targeting — plus linker chemistries and scalable manufacturing with ISO 9001/13485 quality systems.
Bio‑Synthesis designs and manufactures delivery‑enabled oligonucleotides with proven targeting strategies: GalNAc for hepatocytes, DHA/EPA & tocopherol for CNS‑leaning biodistribution, RGD/iRGD and folate for tumor homing, and mannose/lactose plus CPPs (TAT, Penetratin, R9) for immune and general uptake. We integrate conjugation, purification, full analytical QC, and documentation—scaled from discovery to bench‑to‑kilo supply under ISO 9001/13485 with RUO→GMP‑like workflows.
Typical placement uses the 3′ end via short PEG/TEG spacers to preserve hybridization and potency. We offer cleavable linkers (disulfide, Val‑Cit‑PAB, hydrazone, photocleavable PC) to tune release profiles and biodistribution for in vivo work. Manufacturing options include research grade through regulated documentation, with tubes, vials, or plate formatting.
Ask us about multivalency scaffolds (Trebler/Doubler, PAMAM) for avidity or multi‑payload designs.
Gapmers & SSOs with PS/2′‑mods and delivery conjugates.
2′‑OMe/2′‑F/MOE/LNA/cEt, base analogs, L‑DNA/L‑RNA.
3′ caps, 5′ handles, reactive groups for bioconjugation.
Commonly at the 3′ end via a short PEG/TEG spacer to preserve hybridization and reduce steric hindrance. Duplex formats keep the antisense 5′ end clear for Ago2 loading.
Start with tissue: liver→GalNAc; CNS→DHA/EPA/tocopherol/Angiopep‑2; tumor→RGD/iRGD or folate; immune→mannose/lactose/CPPs. Consider linkers and placement to balance exposure and potency.
HPLC/UPLC, LC‑MS, OD260 standard; optional endotoxin, residuals/moisture, and time‑scheduled stability. We support ISO 9001/13485 and RUO→GMP‑like documentation.
Yes—tubes, vials, and plates with barcoding/labels are available. We scale from µmol screens to kilo‑class batches with consistent methods and release QC.
We’ll recommend conjugates, linkers, and placement—then align chemistries and QC for your route and scale.
Please avoid confidential details; we can arrange an NDA if needed.
JavaScript is disabled. The Email button above will open your email client to contact info@biosyn.com.
Trusted by biotech leaders worldwide for over 40+ years of delivering high quality, fast and scalable synthetic biology solutions.