Scale peptides from multi-gram to kilogram quantities with a process-driven approach focused on batch consistency, impurity control, and fit-for-purpose QC. Our chemists support difficult sequences and program-aligned documentation for research through regulated pathways.
Large scale peptide synthesis is not simply increasing batch size. As peptide loads rise, issues such as incomplete coupling, aggregation, scale-dependent impurity growth, and purification recovery can become decisive. Bio-Synthesis applies process development to reduce scale risk and deliver reproducible, well-characterized material.
If your project involves hydrophobic sequences, long peptides, disulfide bonds, phosphorylation, or other complex features, we will recommend a practical synthesis, purification, and QC strategy aligned with your intended use.
Feasibility review, resin/loading strategy, coupling optimization, and impurity controls built for scale.
Scale-appropriate purification planning (including multi-step options) to balance purity and recovery.
COA and optional data packages; support for research through regulated pathway planning.
For the most accurate quoting and fastest start, include these details. If you’re unsure, share your application and we’ll recommend a practical specification.
Need modifications? See Peptide Modifications. For complex sequences, see Difficult Peptide Synthesis.
For regulated needs, see cGMP Peptide Synthesis.
Learn more: Peptide Analytics & QC.
Large-scale projects typically move through feasibility review, optimization/pilot synthesis, full production, and release testing. This structure reduces late-stage failure risk and improves lot-to-lot consistency.
Figure: Large-scale peptide synthesis workflow from feasibility to batch delivery
This workflow reduces late-stage risk and improves lot-to-lot consistency as you move to larger quantities.
Sequence risk assessment, resin/loading strategy, impurity risks, and purification planning.
Optimize coupling/deprotection and confirm purification performance before scaling.
Controlled manufacturing, purification, QC testing, and COA aligned to your requirements.
Tip: Over-specifying purity can reduce yield and increase cost at scale. If you share the application, we’ll recommend a practical target.
Expanded in vivo studies, method development, and reference material.
Consistent peptide lots for assays, controls, and kit manufacturing.
Early alignment for future GMP, clinical, or commercial supply requirements.
Large scale typically refers to production beyond milligram quantities—often tens of grams through kilogram levels depending on sequence complexity and specifications.
Yes. Difficult sequences may require custom strategies and realistic purity/yield expectations. Provide sequence context so we can recommend an appropriate route.
GMP-aligned workflows and documentation can be supported depending on program requirements. Share your quality expectations so we can propose the right pathway.
Common items include HPLC/UPLC purity, mass confirmation, and optional tests such as counter-ion analysis, residual solvents, endotoxin, or bioburden when required.
Sequence (with modifications), target quantity, purity/specs, salt/form, QC requirements, and intended use.
Timelines vary by complexity, scale, purification needs, and QC. A feasibility review enables accurate scheduling upfront.
Not always. Higher purity can reduce yield and increase cost at scale. The best target depends on application sensitivity and whether impurities will impact interpretation.
Yes. If you need smaller quantities quickly, browse Catalog Peptides.
Share your sequence, target scale, purity target, modifications, and QC/documentation needs. Our team will recommend a practical synthesis and QC strategy and provide a quote.
Helpful links: Difficult Peptides • Analytics & QC • cGMP Peptides
Tip: If the peptide is hydrophobic/long/cysteine-rich, include that context so we can route the request to the right synthesis strategy.
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