Post‑synthetic functionalization, reactive handles, and lesion mimics for assay development. Popular options include 5‑F‑dC (TMP‑5‑F‑dU), O6‑Phenyl‑dI, 2‑F‑dI, O4‑Triazolyl‑dU, and m6A—plus halogenated and thio/oxo variants for crosslinking, mutagenesis, and epigenetics.
Convertible base oligonucleotides incorporate bases engineered to be transformed or to provide a reactive leaving group after synthesis. These scaffold bases are used to install probes, form crosslinks, mimic DNA/RNA lesions, or introduce epigenetic marks at defined sites.
O4‑triazolyl‑dU and activated 5‑position pyrimidines undergo substitution with amines, thiols, or azides to install labels or linkers after synthesis.
5‑Br/5‑I pyrimidines and 8‑Br purines support photo/radical crosslinking/footprinting to probe nucleic acid–protein contacts.
Defined modifications such as m6A or oxidized bases serve as standards for reader/writer assays and sequencing controls.
Install dyes, quenchers, biotin, or click handles at a single locus for FRET, hybridization probes, and pull‑down.
Map protein–nucleic acid interfaces using photo/radical‑activated bases (e.g., 5‑Br‑dU).
Introduce convertible lesions or epigenetic marks (m6A) to study repair fidelity and reader proteins.
Send sequence, placement, conversion goal, and purification level—We’ll return a tuned design and QC plan.
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We can align specific literature protocols to your design upon request.
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