Attach redox tags such as Ferrocene, Methylene Blue, Anthraquinone, and Viologen to DNA/RNA for voltammetry, amperometry, and redox-switchable sensing. Offered as NHS, azide/alkyne, maleimide, or ready-made nucleoside analogs (e.g., Fc-dT).
Redox-active modifications introduce electrochemically active functional groups to oligonucleotides, enabling highly specific, label-integrated detection of nucleic acids, proteins, and small molecules—including drugs and metabolites. These sensors operate via target-induced folding or unfolding of an electrode-bound oligonucleotide probe, which alters electron-transfer efficiency upon analyte binding.
In both platforms, the oligonucleotide is typically labeled with a redox-active reporter (e.g., ferrocene or methylene blue) at one terminus and immobilized onto a gold electrode via a thiol–gold bond at the other. Target binding induces conformational changes that modulate redox signal intensity, enabling sensitive, real-time detection—even in complex matrices such as serum or soil.
Representative options; additional variants and custom linkers available on request.
Need a specific redox potential or custom handle (alkyne/azide/amine/thiol)? We can source or synthesize to spec.
We offer site-specific conjugation of redox-active groups to DNA, RNA, and LNA oligonucleotides, with compatibility across:
Release payloads under reducing or acidic conditions; ideal for triggered probe activation.
Redox-, photo-, or pH-responsive spacers for controlled signal switching.
Custom-designed probes for DPV/SWV voltammetry and amperometric readouts.
Fc/MB/Viologen-enabled attachment strategies for electrodes and sensor chips.
Please avoid confidential details; we can arrange an NDA if needed.
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