Therapeutic Oligonucleotide Service from Bio-Synthesis
Therapeutic oligonucleotides are short, synthetic nucleic acid molecules used to regulate gene expression for research, preclinical, and drug development applications. Common formats include siRNA, antisense oligonucleotides (ASOs), splice-switching oligonucleotides (SSOs), and other modified RNA or DNA constructs.
Bio-Synthesis provides custom oligonucleotide synthesis, chemical modification, bioconjugation, purification, scale-up, and analytical QC support for RNA-targeted and oligonucleotide-based programs.
Therapeutic oligonucleotide workflow: design, modification, conjugation, delivery, and biological activity.
Modalities
siRNA / ASO
Plus SSO and modified oligos
Chemistry
Modified
2′-OMe, 2′-F, PS, LNA
Conjugation
Targeted
GalNAc, lipid, peptide, ligand
QC
HPLC / MS
Purity and identity support
Bio-Synthesis specializes in custom oligonucleotide synthesis with rapid turnaround, flexible scale-up, and full-spectrum support from RUO to cGMP. Our facility produces microgram to multi-gram quantities to match your evolving development needs.
Scale
Microgram to multi-gram synthesis capabilities
Speed
Rapid turnaround for custom oligo programs
Flexibility
Client-centric support from feasibility to development
Quality
Manufacturing under ISO 13485-certified quality standards
Compact development pathway from R&D and analytical development through preclinical and clinical-stage support.
From early feasibility through clinical development, Bio-Synthesis supports therapeutic oligonucleotide programs with reliable synthesis, precise modification, scalable production, and quality-focused documentation.
Custom synthesis support for therapeutic and preclinical oligonucleotide programs, including RNA, DNA, and modified oligo constructs.
Modification options help improve stability, nuclease resistance, binding behavior, and application-specific performance.
Bioconjugation options support targeting, uptake, tracking, and delivery-oriented development workflows.
This page provides a high-level overview of common oligonucleotide modalities supported for therapeutic and preclinical applications.
GalNAc conjugation is commonly used for liver-targeted oligonucleotide delivery strategies.
Lipid conjugates and lipid nanoparticle workflows support delivery-oriented oligonucleotide development.
Peptides, ligands, and reactive handles can support targeted delivery, uptake studies, and custom conjugate design.
Programs can be configured for research, preclinical, and development-stage needs with appropriate scale, purification, and documentation.
Analytical support can include purity, identity, and application-specific quality testing depending on the program scope.
Bio-Synthesis delivers consistent quality across every stage of your oligonucleotide program — from early research through development and scale-up.
Our quality-driven processes support reproducibility, regulatory alignment, documentation, and transparency, giving you confidence in every batch produced.
High-quality custom siRNA synthesis with flexible design formats, chemical modifications, conjugation options, and scalable production support.
Antisense oligonucleotide synthesis with advanced modification options and support for research, preclinical, and therapeutic applications.
Custom oligonucleotide conjugation services including GalNAc, lipid, peptide, ligand, linker, and reactive-handle strategies.
Services include custom synthesis, chemical modification, bioconjugation, purification, scale-up, and analytical QC support for therapeutic and preclinical oligonucleotide programs.
Supported modalities include siRNA, ASO, splice-switching oligos, modified RNA constructs, modified DNA constructs, and conjugated oligonucleotides.
Yes. Modification and conjugation options include 2′-OMe, 2′-F, phosphorothioate, LNA, GalNAc, lipid, peptide, ligand, linker, and reactive-handle chemistry.
Yes. Programs can be supported from early RUO feasibility through development and cGMP-oriented manufacturing support, depending on oligo type, scale, documentation, QC, and project requirements.
Useful information includes oligo type, sequence or target, modification needs, conjugation requirements, scale, purification, QC needs, and intended application.
For the fastest response, share the oligo modality, sequence or target, modification and conjugation needs, desired scale, purification requirements, QC expectations, and intended application.
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