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Research-Grade Oligonucleotide Synthesis

Custom research-grade oligonucleotide synthesis for advanced molecular biology, genomics, and diagnostic research workflows.

Custom DNA Oligos Custom RNA Oligos Modified Oligos PCR & qPCR NGS & CRISPR Purification & QC Research Use Only ISO 9001 Certified
Research Applications

Research-Grade oligonucleotides designed around your research workflow

OligoLS™ supports molecular biology, assay development, discovery research, and diagnostic development workflows where sequence accuracy, modification flexibility, purification strategy, and analytical confidence matter.

PCR Primers, qPCR Probes, NGS Oligos, CRISPR Guide RNA, and Research Probes

PCR Primers qPCR Probes NGS Adapters CRISPR Guide RNA Molecular Beacons FISH Probes siRNA Research Synthetic Biology

PCR & qPCR

Custom primers, probes, fluorescent reporters, quenchers, and assay-ready oligos for amplification and quantitative detection workflows.

NGS & Sequencing

Adapters, indexes, barcodes, capture probes, and custom oligos supporting sequencing library preparation and targeted analysis.

CRISPR & Gene Editing

Guide RNAs, donor templates, modified oligos, and design-supporting synthesis options for genome editing and functional studies.

Probe Development

FISH probes, molecular beacons, labeled probes, dual-labeled probes, and specialty oligos for imaging and detection workflows.

Molecular Diagnostics

Research-use oligos for assay development, validation studies, pathogen detection, genetic testing research, and biomarker analysis.

RNA Research

RNA oligos, modified RNA, siRNA research tools, antisense research oligos, and constructs for gene expression studies.

Conjugated Oligos

Biotin, fluorophore, linker, thiol, amino, lipid, peptide, and other conjugation-ready oligos for specialized applications.

Advanced Research

Custom oligo designs for synthetic biology, biomarker research, target validation, screening, and exploratory molecular biology workflows.

Features & Benefits

Built for reliable research performance, not just oligo ordering

OligoLS™ is designed for research teams that need dependable oligonucleotide synthesis, flexible chemistry options, and practical technical support for assay-driven molecular biology workflows.

Feature

Application-aware synthesis

Oligos can be specified around the actual research workflow, not only sequence and scale.

  • PCR, qPCR, NGS, CRISPR, probe, and diagnostic research support
  • Application-driven recommendations for purification and QC
  • Support for standard and complex oligo designs

Benefit

More confidence downstream

Better alignment between synthesis, purification, modification, and application can reduce troubleshooting during downstream experiments.

  • Options for HPLC, PAGE, cartridge, or desalt purification
  • Analytical support for identity and purity expectations
  • Useful for assay-sensitive and modification-heavy projects

Advantage

Specialty chemistry access

Bio-Synthesis supports modified, labeled, conjugated, and difficult oligo designs that basic catalog-style ordering systems may not handle well.

  • Fluorophores, quenchers, linkers, biotin, thiol, amino, and specialty groups
  • Backbone, base, sugar, and terminal modifications
  • Pathway to scale-up or development support when needed
Modification Flexibility

Modified DNA and RNA Oligonucleotide Chemistry

Bio-Synthesis supports standard and specialty oligonucleotide modifications to help researchers design oligos for detection, binding, stability, conjugation, imaging, sequencing, and functional studies.

Modified Oligonucleotides for Detection, Stability, Labeling, and Conjugation

Labels & Detection

  • Fluorescent dyes
  • Quenchers
  • Dual-labeled probes
  • Biotin and affinity tags

Linkers & Functional Groups

  • Amino modifications
  • Thiol modifications
  • Spacer and linker chemistry
  • Click-ready handles

Backbone & Base Modifications

  • Phosphorothioate linkages
  • Modified bases
  • 2′ modifications
  • Stability-oriented designs
Purification & QC

Research-Grade Oligonucleotide Purification & QC Options

Research-grade oligos can require different purity, yield, and analytical strategies depending on application, length, modification, and assay sensitivity.

Desalt, Cartridge, PAGE, HPLC, and Analytical QC Support

Option Best For Why It Matters
Desalt Standard primers and routine molecular biology use. Cost-effective option for many PCR and basic research workflows.
Cartridge / RP Purification Moderate purity needs and selected modified oligos. Improves product quality for assays that need better cleanup than desalt.
PAGE Purification Longer oligos, sequence-sensitive applications, and higher-resolution separation. Helps isolate full-length product from truncated synthesis products.
HPLC Purification Modified oligos, probes, labeled oligos, and demanding assay workflows. Supports improved purity for complex or high-value research applications.
Analytical QC Identity, purity, and documentation support. Provides confidence for downstream research performance and troubleshooting.
Workflow

Research Oligonucleotide Synthesis Workflow

OligoLS™ supports researchers with flexible synthesis, modification, purification, and analytical workflows designed for advanced molecular biology applications.

CDMO capabilities workflow from research and discovery to custom synthesis, chemistry development, and therapeutic development
Research → Chemistry Development → Therapeutic Development
Why Choose Bio-Synthesis

Why Choose Bio-Synthesis for Research-Grade Oligonucleotide Synthesis

Bio-Synthesis combines research-use oligonucleotide synthesis with deeper custom chemistry capabilities, helping scientists move from routine primer ordering to more complex modified, labeled, conjugated, and assay-critical oligo designs.

45+
Years of Expertise

Long-standing custom synthesis experience supporting biotechnology, pharmaceutical, diagnostic, and research organizations.

ISO

Quality-focused workflows for research-use oligonucleotide synthesis, documentation, and customer support.

DNA/RNA
Custom Oligos

Support for standard, modified, labeled, conjugated, and assay-critical oligonucleotide designs.

QC
Analytical Support

Purification and analytical options matched to routine primers, sensitive probes, modified oligos, and demanding assay systems.

Research-Grade Oligonucleotide Synthesis FAQ

Common questions about OligoLS™ research-use oligos, modification options, purification choices, and when to request technical guidance.

Start Your Oligo Project

Discuss Your Research Oligonucleotide Project

Share your sequence, modification, purification, scale, and application requirements. Bio-Synthesis can help align custom DNA and RNA oligonucleotide synthesis with your research workflow.
DNA & RNA Oligos
Modifications & Labels
Purification & QC
Partner with a leader in custom synthesis CDMO solutions and therapeutic development support

Need Design Guidance?

Discuss modifications, purification strategies, long oligos, probes, or application-specific synthesis requirements with our scientific team.

Contact Us →

Know Your Sequence?

Submit sequence, scale, modification, purification, and delivery requirements for project review.

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Why Choose Bio-Synthesis

Trusted by biotech leaders worldwide for over 45+ years of delivering high quality, fast and scalable synthetic biology solutions.