Multivalent peptides: what they are (and what they are not)
Bio-Synthesis provides custom multivalent peptide synthesis as a dedicated service, supporting research programs that require controlled epitope density, enhanced avidity, or receptor clustering beyond what linear peptides can achieve. With over 45 years of peptide manufacturing experience, our team designs and synthesizes multivalent constructs using MAP peptides (MAP-2/4/8), lysine- and diamino-acid branching, dendrimeric cores, and modular click-assembled architectures—selected based on spacing, steric constraints, solubility, and downstream application requirements.
Unlike catalog-driven offerings, our multivalent peptide service emphasizes design review, synthesis feasibility, purification planning, and fit-for-purpose QC. We work closely with customers to control branch-point fidelity, minimize mixed-arm products, and deliver constructs suitable for immunology, receptor clustering, diagnostic assays, and discovery workflows, with analytical documentation aligned to screening or assay-grade needs.
Each project is reviewed by experienced peptide chemists to ensure the selected multivalent strategy is practical to synthesize, analytically interpretable, and aligned with experimental goals—not just theoretically multivalent.
Branch peptide
Dendrimeric cores
Strategy-fit-for-purpose
ISO 9001:2015/ISO13485:2016
45+ Years of Expertise
U.S. Facilities - Texas
Higher avidity
Multiple motifs can increase functional binding strength through multivalent interactions.
Receptor clustering
Multivalency can drive clustering/engagement when mono-valent ligands underperform.
Signal amplification
More binding events per molecule can improve capture/detection assays (design-dependent).
Figure: Common multivalent peptide architectures—MAP/branched formats, dendrimeric cores, and click-assembled modular designs.
Multivalent peptide synthesis
MAP peptide synthesis
Branched peptides
Dendrimeric peptides
Click chemistry peptides
Hetero-branched peptides
Related services:
Custom Peptide Synthesis,
Peptide Modifications,
Peptide Bioconjugation,
Click Chemistry Peptides.
For ready-made options, browse Catalog Peptides.
Common requests: MAP-2/4/8 peptide synthesis, multivalent epitope constructs, receptor-clustering ligands, and modular click-assembled multivalent probes (project-dependent).