End-to-end conjugation of drug payloads, fluorophore labels, affinity tags, chelators/radiometals, nanoparticles, and oligonucleotides to antibodies, proteins, peptides, and surfaces. ISO 9001/13485 systems with LC-MS/HPLC-verified QC.
Bio-Synthesis offers comprehensive conjugation of payloads, labels, and tags across biomolecules—antibodies, proteins/enzymes, peptides, oligonucleotides, nanoparticles, and device surfaces. We combine NHS-ester, maleimide–thiol, click chemistries (DBCO↔Azide, TCO↔Tetrazine), and glycan/enzymatic routes to deliver high-performance conjugates with controlled substitution and preserved activity.
Typical deliverables include ADC-like prototypes, fluorescent and biotinylated antibodies, chelator/radiometal constructs for imaging, DNA-barcoded antibodies, and nanoparticle conjugates for LFA and biosensors—each supported by a fit-for-purpose QC package.
Learn more about our antibody conjugation services and other custom conjugation capabilities.
*For re-bridging, use mild partial reduction (e.g., TCEP ≤1 mM, 5–10 min, RT) to expose hinge thiols, then add bis-maleimide and quench residual linker.
Use NHS for fast, broad amine labeling; maleimide for thiol-selective control; click for orthogonal dual labels or fragile targets; glycan/enzymatic when you need site-specific uniformity.
LC-MS (intact/subunit), HIC for F/P or DAR, SEC-MALS for aggregation, and binding/activity (ELISA/SPR/BLI). For biotin, HABA or streptavidin binding; for dyes, spectral and free-dye check.
Yes—via orthogonal click pairs (DBCO↔Azide and TCO↔Tetrazine) or mixed thiol/amine routes. We validate each payload’s loading and function independently.
Biomolecule identity, buffer & concentration, desired chemistry, target F/P or DAR, QC needs, and return format. For small molecules/oligos, include purity, solvent, and reactive handle.
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