Custom lipidated peptides and lipid–peptide conjugates with site-defined attachment—designed for reproducibility, assay-ready performance, and scalable delivery.
Bio-Synthesis provides custom lipopeptide synthesis and lipid–peptide conjugation services for projects where lipidation changes function—improving membrane association, enabling amphiphilic self-assembly, enhancing delivery, or introducing immune-active lipid motifs.
We support N-terminal acylation (N-lipidation), side-chain lipidation (e.g., Lys ε-amine), and site-selective conjugation (e.g., Cys handles). Each project is planned using sequence-aware SPPS (and fragment strategies when needed) with protecting-group orthogonality to control selectivity and reduce product heterogeneity.
Deliverables are aligned to your decision needs, with a fit-for-purpose purification and QC strategy (HPLC/MS standard; expanded testing available) to ensure the final material is usable in formulation, binding, immunology, or mechanistic studies.
A defined attachment site reduces mixtures and improves batch-to-batch reproducibility.
Hydrophobicity and aggregation risks are planned up front to protect yield and purity.
HPLC/MS standard; optional analytics selected based on formulation and downstream requirements.
Related services: Peptide Modifications, Vaccine Peptides, Peptide Conjugates. For ready-made options, browse Catalog Peptides.
A lipopeptide is a peptide bearing a covalently attached lipid (fatty acid, sterol, or amphiphile). The lipid can increase membrane affinity, drive supramolecular assembly, and tune distribution or immune engagement depending on the architecture.
Lipidation can easily create mixtures if multiple reactive sites exist (e.g., multiple Lys residues). Site-defined designs improve interpretability and reproducibility across assays and batches.
A direct and common architecture. Typically yields one dominant product when the N-terminus is uniquely available.
Lipid attached to a defined residue (commonly Lys ε-amine) to preserve N-terminus or control presentation.
Attach the lipid to the peptide C-terminus (e.g., via C-terminal carboxylate or a defined C-terminal handle) to preserve N-terminal motifs or control orientation.
A compact schematic comparing site-defined side-chain lipidation with handle-based late-stage conjugation for modular lipid screening.
Late-stage modular lipidation using a defined handle—ideal for screening lipid variants on one peptide core.
Below is a practical list of commonly requested lipid moieties. Availability and the best route depend on the lipid structure, desired attachment chemistry, sequence behavior, and whether you need a single defined product.
Not sure what lipid to choose? Tell us your target (membrane anchoring, self-assembly, immune activation, or PK tuning) and the assay/formulation constraints. We’ll recommend a practical design and QC plan aligned to your decision.
Confirm sequence, lipid target, attachment site(s), and any required handles (azide/alkyne, cysteine, biotin, etc.).
SPPS of peptide core + on-resin or solution lipidation; fragment strategies available for challenging designs.
Deliver assay-ready material with identity/purity documentation and optional characterization as needed.
Buyers searching “lipopeptide synthesis” typically compare vendors on site definition, control of mixtures, technical transparency, and QC clarity. Use this checklist to evaluate any provider.
If you want ready-made peptides (non-lipidated), see Catalog Peptides. For defined lipidation, request a custom quote.
If your goal is to compare lipid variants, prove site definition, or support regulated workflows, tell us what the data must demonstrate—then we’ll recommend the right options.
Use this as a checklist for your quote request. If you’re unsure, send your sequence(s) and goal—we’ll propose options.
Yes. We support N-terminal acylation, C-terminal lipidation (project-dependent), and site-defined side-chain lipidation (commonly Lys). We also support handle-based strategies for Cys-selective or modular lipidation when appropriate.
Send your peptide sequence(s), lipid identity (or goal if undecided), desired attachment site(s), target quantity/purity, and downstream use. If you need a single defined product, tell us whether multiple Lys/Cys are present.
We plan protecting-group orthogonality and choose a single defined attachment site (or a dedicated handle) to reduce heterogeneous products and improve reproducibility.
Standard deliverables typically include MS identity confirmation, an HPLC profile, and a COA. Optional testing (endotoxin, residual solvents, peptide content, expanded documentation) can be added on request.
Often yes. If you need matched controls (peptide core vs lipidated version), include that in your quote request so we can align synthesis and QC.
Lipidation increases hydrophobicity and can increase aggregation, reduce solubility, and broaden chromatographic peaks. A design-led plan (site definition, linkers/handles, and tailored purification) reduces risk.
Share your sequence and goal—we’ll recommend a practical lipidation strategy and QC plan aligned to your application.
For fastest turnaround, include whether multiple Lys/Cys sites exist and whether a single defined product is required.
A short, high-signal reference set for lipopeptide synthesis and lipid–peptide conjugation. For design context on attachment-site choices, see: N-terminal lipidation, C-terminal lipidation, and side-chain lipidation.
If you need a longer curated list (e.g., for Pam2/Pam3 motifs, cholesterol conjugates, or PEG-lipids), request it during design review.
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