Peptide–drug conjugates (PDCs) are hybrid molecules where a therapeutic small-molecule drug payload is
covalently linked to a peptide carrier through a chemical linker. In a cleavable linker PDC,
the linker is designed to be broken under specific biological conditions (project-dependent), enabling payload release after
the conjugate reaches a target environment.
Cleavable linker peptide–drug conjugates (PDCs) are explored when controlled payload release is desired in defined biological environments. This page summarizes cleavable linker PDC synthesis, enzyme-cleavable PDC linker concepts, site-specific PDC conjugation considerations, and how Bio-Synthesis peptide drug conjugation services support research-stage and preclinical programs.
The peptide portion may function as a targeting ligand, cell-penetrating element, or molecular scaffold,
while the payload contributes pharmacological activity. Cleavable linkers are commonly explored to balance systemic stability with
controlled release in the intended compartment (e.g., intracellular space, acidic microenvironments, or enzyme-rich regions).
Important: “Cleavable vs non-cleavable” is a linker strategy, not a payload category.
Payload class (oncology drugs, antibiotics, antivirals, etc.) is selected separately.
Cleavable vs non-cleavable PDCs: cleavable linkers are explored when controlled release is part of the design goal, while non-cleavable linkers are often used when maximum linkage stability is required for mechanistic studies or profiling. Bio-Synthesis supports both approaches as part of custom peptide–drug conjugates development (project-dependent).
If you are searching for custom peptide drug conjugates PDC synthesis with cleavable linkers, Bio-Synthesis can support fit-for-purpose designs (project-dependent) from sequence planning through conjugation, purification, and analytical confirmation.
Release concept
Design the linker to remain stable during handling and circulation, then cleave in the intended environment (project-dependent).
Attachment control
Use site-specific handles (single Cys, click handles, defined termini) to reduce heterogeneity and improve reproducibility.
Analytical fit
Confirm identity and purity by HPLC/UPLC and LC-MS when feasible; align deliverables to intended use.
Figure: Cleavable linker peptide–drug conjugate (PDC) architecture showing peptide carrier, cleavable linker (e.g., Val–Cit–PABC or disulfide), and small-molecule drug payload.