Peptide–lipid conjugates are hybrid molecules in which a peptide is covalently linked to a lipid or lipid-derived moiety through a defined chemical linkage.
By combining peptide binding/transport properties with lipid-driven hydrophobicity and membrane interaction, peptide–lipid conjugation is explored as a strategy to
tune biodistribution, uptake, and exposure during research and early development (project-dependent). [1], [2]
In a typical design, the peptide may function as a targeting ligand, receptor-binding element, or cell-penetrating sequence, while the lipid contributes membrane affinity and/or
serum protein binding behavior. [3] [2] Attachment site selection and linker chemistry strongly influence solubility, aggregation tendency, and functional performance.
Peptide–lipid conjugates
Fatty acid–modified peptides
Palmitoylated peptides
Cholesterol-conjugated peptides
PEG-lipid conjugates
45+ Years of Expertise
U.S. Facilities – Texas
Bio-Synthesis provides custom peptide–lipid conjugation and peptide lipidation services to support
discovery-stage and preclinical research programs. Our approach is design-led and sequence-aware, with conjugation
strategies selected based on the peptide structure, lipid chemistry, attachment site constraints, and intended
downstream application. We support fatty acid–modified peptides, cholesterol-conjugated peptides,
PEG-lipid designs, and cleavable lipid attachment concepts using site-defined chemistries to minimize heterogeneity
and preserve peptide functionality.
Related capability: Peptide–drug conjugation services
Figure: Peptide–lipid conjugate architecture showing peptide carrier, lipid moiety (fatty acid or cholesterol), and chemical linkage.
Vendor-safe note: Lipid selection, attachment site, and linkage type are determined on a project-specific basis
based on peptide sequence,
lipid chemistry, and intended use.