Specialized synthesis formats that go beyond routine SPPS—multivalent architectures, conformational constraints, hybrid conjugates, precision handles, and discovery-ready libraries. Use this hub to jump into detailed service pages.
Need standard services? See Custom Peptide Synthesis.
Topologies that increase epitope density, avidity, or enable site-specific functionalization.
Multi-arm peptides built from a defined branching point to increase functional density or enable multi-epitope formats.
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Dendrimeric constructs that present multiple copies of an epitope without carrier proteins for antibody and vaccine workflows.
Peptides engineered to display multiple motifs to improve receptor engagement, potency, or immune recognition.
Strategic cysteine placement for site-specific conjugation or controlled cyclization while minimizing off-target thiol chemistry.
Representative architectures for branched, MAPs, multivalent, and cysteine-selective peptide designs.
Formats designed to stabilize bioactive conformations and improve binding specificity or proteolytic stability.
Cyclic formats (head-to-tail or side-chain) that improve stability and binding by locking peptides into defined geometries.
Helix-stabilized peptides using side-chain “staples” to enhance affinity, protease resistance, and functional performance.
Large cyclic peptides produced via head-to-tail or side-chain cyclization to enhance stability, selectivity, and target engagement.
Two-ring constrained peptides that increase rigidity and specificity—useful for high-affinity binders and challenging targets.
Conformation-biased designs that stabilize secondary structure (e.g., helix-promoting residues or constraints) for improved activity.
Visual: helix stabilization via a side-chain staple.
Peptides combined with lipids, glycans, oligonucleotides, or small molecules to create multifunctional constructs.
Peptides bearing defined carbohydrate moieties for immunology, receptor recognition, and glyco-epitope studies.
Peptides conjugated to lipid chains to support membrane interaction, delivery strategies, or immune activation.
Hybrid constructs combining peptides with oligonucleotides (DNA/RNA/PNA/PMO) for targeting, delivery, or mechanistic studies.
Peptides chemically linked to small molecules to add functionality, targeting, or pharmacology to a peptide scaffold.
Examples of peptide–oligonucleotide and peptide–drug conjugate architectures.
Build in measurement, release, or downstream chemistry with isotope labels, cleavable linkers, and click-ready handles.
Stable isotope incorporation for quantitative LC–MS/MS, pharmacokinetics, or metabolic studies.
Peptides with enzyme- or condition-sensitive linkers (pH/redox/protease) for triggered cleavage and payload release.
Peptides with bioorthogonal handles for rapid, site-specific conjugation (e.g., azide/alkyne or tetrazine ligations).
Formats optimized for screening, mimicry, and immunology tools.
Peptide-like molecules designed to retain bioactivity while improving stability, permeability, or proteolysis resistance.
Peptide–MHC complexes produced for antigen-specific T-cell detection, immune profiling, and flow cytometry applications.
Library-based synthesis generating large collections of related sequences for high-throughput screening and hit discovery.
Share your sequence(s), intended application, purity/scale needs, and any labels or conjugations. We’ll recommend a practical strategy and provide a quote.
Tip: If your project includes multiple sequences (libraries), tell us the count and any shared specifications to speed quoting.
No. This is an advanced synthesis hub (how peptides are built). Modifications (e.g., labels, PEG, cyclization chemistry) can be separate pages and linked from the relevant services.
Provide sequences (or a spreadsheet), desired purity/scale, required handles (e.g., cysteine, click), and your application. We’ll recommend the most robust build + QC plan.
Often, yes. Constrained, hybrid, and library workflows can add steps (special reagents, orthogonal protection, extra QC). We’ll align expectations in the quote.
Yes—each card is designed as a gateway. Keep this hub short, and place specs, options, and deeper FAQ content on the linked pages.
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