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Custom Research-Grade Peptide Synthesis

Research peptides built to your sequence and specs — choose purity, scale, and modifications, with HPLC/MS quality control and a Certificate of Analysis (COA). Our scientists can recommend practical specifications based on your application and sequence risk.

Request a Quote Specifications FAQs
SPPS (Fmoc)
Purity: crude → ≥95%
HPLC + MS QC
COA included
Modifications & Labels
Overview Customizable Specifications Modifications Purification & QC Difficult & Specialized Peptides SPPS Workflow Applications Contact

Overview

Bio-Synthesis provides custom research-grade peptide synthesis for academic, biotech, and pharmaceutical research. We synthesize sequence-defined peptides using established solid-phase peptide synthesis (SPPS) methods and deliver peptides with documentation and analytics appropriate for reproducible laboratory work.

If you’re ordering a sequence with known challenges (hydrophobic, long, cysteine-rich, aggregation-prone), share that context and we’ll recommend a practical synthesis and QC approach.

ISO 9001:2015 / ISO 13485:2016 U.S. Facility – Lewisville, Texas 45+ Years of Expertise Confidential & IP-Protected Research to Scale-Up Support
Quick Specs (Research-Grade)
  • Workflow: SPPS (Fmoc)
  • Purity: crude / ≥70% / ≥90% / ≥95%
  • Scale: µg → mg → g (project-dependent)
  • QC: HPLC purity profile + MS identity
  • Documentation: COA included

Not sure what to choose? Tell us your assay type and we’ll recommend a fit-for-purpose spec.

Fastest Quote Checklist
  • Sequence(s) + length
  • Purity target (crude / ≥70% / ≥90% / ≥95%)
  • Quantity (µg / mg / g)
  • Modifications/labels (N-/C-termini, biotin, fluor, etc.)
  • Preferred salt form (if needed)
Request a Quote Speak to a Scientist
Sequence & Specs
Purity · Scale · Mods
➜ ↓
Synthesis (SPPS)
Stepwise assembly
➜ ↓
Purification
Desalt / Prep HPLC
➜ ↓
Analytics & QC
HPLC · MS · COA
➜ ↓
Delivery & Support
Guidance
Need a Peptide Quickly?

In addition to custom synthesis, Bio-Synthesis offers a wide selection of ready‑made, on‑demand catalog peptides. If your sequence is already available, catalog peptides can provide faster delivery for common research applications.

Browse catalog peptides →

Already Have a Standard Sequence?

For many common targets, you may not need full customization. Explore our ready‑made catalog peptides available on demand, then use custom synthesis when you need specific purity, scale, or modifications.

See catalog availability →

Customizable Specifications

Research-grade peptides can be tailored for your experiment. Select options based on use case, and we can advise if you’re unsure.

Purity
  • Crude / desalted
  • Purified (≥70%, ≥90%, ≥95%)
  • Guidance by application
Quantity
  • µg / mg / g
  • Scale-up planning available
  • Batch consistency options
Modifications & Labels
  • N-/C-terminal modifications
  • Biotin, fluorophores, tags
  • Custom functional handles
Table: Research-grade peptide options (quick reference).
Option Typical choices When to use Included QC
Purity Crude / ≥70% / ≥90% / ≥95% Screening → quantitative assays HPLC profile + COA
Quantity µg / mg / g Pilot studies → follow-up work COA
Identity Sequence confirmation Always recommended MS (LC‑MS or MALDI‑MS)
Modifications N-/C-termini, labels, tags Detection, conjugation, imaging Project‑appropriate QC
Difficult sequences Hydrophobic / long / cysteine‑rich When standard synthesis is risky Recommended strategy + QC

For challenging sequences, see Difficult Peptide Synthesis.

Peptide Modifications & Labels

Bio-Synthesis supports a wide range of peptide modifications and labels to meet experimental and assay-specific requirements. Modifications can be introduced during synthesis or post-synthetically, depending on chemistry and sequence design.

Terminal Modifications
  • N‑terminal acetylation
  • C‑terminal amidation
  • Custom terminal functionalization

Explore terminal modifications →

Labels & Tags
  • Biotinylated peptides
  • Fluorescent labels (FITC, TAMRA, Cy dyes)
  • Affinity and detection tags

Explore labels & tags →

Specialty Modifications
  • Phosphorylated peptides
  • Methylated peptides
  • Non‑natural amino acids

Explore specialty mods →

Peptide Bioconjugation

Conjugate custom peptides to carrier proteins and other molecules to support immunization, detection, and assay development. Our scientists can recommend conjugation chemistry and linker strategy based on your target and application.

  • Peptide–oligonucleotide conjugates: DNA/RNA (siRNA, miRNA, ASO, aptamers) for gene delivery, antisense research, and diagnostics
  • Peptide–protein conjugates: enzymes, antibodies, and fragments (research and therapeutic development)
  • Peptide–carrier protein conjugates: KLH, BSA, Ova for antibody production
  • Peptide–peptide conjugates: multivalent designs (dimers/trimers), CPP cargo, and signaling peptides for affinity enhancement, stability, and delivery
  • Peptide–small molecule conjugates: drugs, inhibitors, agonist/antagonists for targeted drug delivery
  • Peptide-polymer:PEG, polypeptide, synthetic polymers (PLGA, HPMA) dendrimer for stability, solubility, half-life extension
  • Peptide-lipids: Fatty acids, cholesterol, lipopeptides for membrane anchoring, half-life extension, delivery
  • Fluorophores & imaging agents: organic dyes, near-infrared dyes, radiolabel chelators for imaging, diagnostics, and tracking
  • Peptide-sugars and Targeting Moieties: GalNAc, mannose, folic acid, RGD motifs (as ligands) for cell-specific targeting.
  • Custom linker and spacer chemistry

Explore peptide bioconjugation →

If you need multiple modifications (e.g., label + phosphorylation) or complex designs, our scientists can advise on feasibility and optimal synthesis strategy.

Purification & Quality Control (QC)

Standard analytics
  • HPLC purity profiling
  • Mass spectrometry (MS) identity confirmation
  • Certificate of Analysis (COA)
Why QC matters
  • Improves reproducibility across experiments
  • Reduces variability from truncations/side products
  • Confirms identity before conjugation or formulation

Need a purity recommendation? Tell us your assay type (screening vs quantitative) and we’ll suggest a practical target.

Additional Analytical & Testing Services
  • Endotoxin testing (research-use requests)
  • Residual solvent / residual chemical analysis
  • Water content determination (Karl Fischer)
  • Salt exchange and salt form confirmation
  • Custom analytical requests aligned to your workflow

Availability of add-on testing depends on peptide specifications and intended research use. Contact our scientists for guidance.

Difficult & Specialized Research Peptides

Long Peptides

Long sequences can reduce coupling efficiency and complicate purification.

Long peptide synthesis →

Hydrophobic Peptides

Hydrophobic sequences may aggregate; strategies can improve success.

Hydrophobic peptides →

Cysteine-Rich Peptides

Specify reduced vs oxidized form and any disulfide requirements.

Cysteine-rich peptides →

If your sequence is aggregation-prone or heavily modified, share your sequence and application and we’ll recommend an appropriate strategy for synthesis, purification, and QC.

Why Choose Bio-Synthesis for Research Peptides?

In‑House Synthesis & QC

Custom synthesis and analytical characterization performed under one roof for consistent execution.

Scientist‑to‑Scientist Support

Discuss sequence risks, purification strategy, and practical specs directly with peptide scientists.

Sequence‑Specific Problem Solving

Optimized approaches for hydrophobic, long, cysteine‑rich, and aggregation‑prone peptides.

Tip: If you’re matching literature conditions or planning downstream conjugation, include that context so we can recommend a fit‑for‑purpose purity target, salt form, and analytical package.

Solid-Phase Peptide Synthesis (SPPS) Workflow

Core SPPS Cycle
  • Deprotection (repeated each cycle): remove the temporary N-terminal protecting group.
  • Activation & Coupling (repeated each cycle): add the next amino acid to the growing chain.
  • Final cleavage: release the completed peptide from the resin and remove side-chain protecting groups.

Use your corrected schematic here to visually reinforce the repeating cycle and the single final cleavage step.

Schematic solid-phase peptide synthesis workflow showing repeated deprotection and coupling cycles and final cleavage from resin

Typical Research Applications

  • Immunology & epitope mapping
  • Cell signaling & receptor studies
  • Enzyme assays & inhibitor screening
  • Protein–protein interaction studies
  • Assay development & validation
  • Conjugation and labeling workflows

FAQ

Do you offer peptide bioconjugation (e.g., KLH/BSA conjugates)?

Yes. Bio-Synthesis offers peptide bioconjugation, including peptide–carrier protein conjugates (such as KLH or BSA) and other custom conjugates. Share your peptide sequence, desired carrier/target, and application and we’ll recommend a suitable conjugation approach and QC documentation.

What is a research-grade peptide?

A research-grade peptide is a chemically synthesized peptide intended for laboratory research applications. Most research peptides are produced using solid-phase peptide synthesis (SPPS), which allows precise control over amino acid sequence and compatibility with a wide range of chemical modifications. Research-grade peptides are typically supplied at microgram-to-gram scale and are not intended for clinical or therapeutic use.

What purity level do I need for research peptides?

Many in vitro assays use ≥90–95% purity, while early screening may tolerate lower purity. Tell us your application and we’ll recommend a practical target.

How long does custom peptide synthesis take?

Lead time depends on sequence length, complexity, modifications, purification level, and scale. Your quote includes an estimated ship date.

Do you provide HPLC/MS and a COA?

Yes. Standard characterization includes HPLC purity profiling and MS identity confirmation, documented in a Certificate of Analysis (COA).

Can you synthesize difficult peptides?

Yes. We support hydrophobic, long, cysteine-rich, and aggregation-prone sequences, with tailored synthesis and purification strategies.

More FAQ'sAll FAQ's
CONTACT US

Speak to a Peptide Scientist

Share your sequence(s), intended application, purity/scale needs, and required modifications. We’ll recommend practical specifications and provide a quote.

Request a Quote Contact Form

Tip: If the peptide is hydrophobic/long/cysteine-rich, include that context so we can route the request to the right synthesis strategy.

Why Choose Bio-Synthesis

Trusted by biotech leaders worldwide for over 40+ years of delivering high quality, fast and scalable synthetic biology solutions.

Greetings Researchers,

Please be advised that any information, guidelines, writeups, and oral/video/graphic content on our website are intended solely as general guidelines.
It is the researcher's sole responsibility to conduct thorough research on the designs of the products intended for their experiments before submitting
their designs to Biosynthesis for review of production feasibility.
Thank you for your understanding.

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