Non-radioactive peptide–chelator conjugates designed as radioligand precursors for imaging workflows
Radiolabel-compatible peptide chelator conjugates are non-radioactive peptide constructs in which a metal-chelating ligand is covalently attached to a peptide to enable downstream coordination of radiometals. These constructs are commonly used as radioligand precursors for imaging and tracer-development workflows (project-dependent).
In this workflow, Bio-Synthesis provides the chelator-enabled peptide precursor (purified and analytically confirmed), while radiolabeling is performed by the end user in an appropriate radiochemistry setting. Bio-Synthesis does not perform radiolabeling or handle radioactive materials.
Compared to radiochemistry-focused vendors, Bio-Synthesis specializes in the upstream synthesis of non-radioactive peptide–chelator conjugates, enabling researchers to control peptide sequence, attachment site, and chelator architecture before radiolabeling.
Successful chelator–peptide designs depend on chelator class (macrocyclic vs acyclic), attachment site selection, and spacer/linker strategy to maintain peptide binding and improve handling. We support representative chelators including DOTA, DO2A, DO3A, DOTP, TACN, NOTA, and TETA, and we can evaluate user-specified chelators (project-dependent).
Radiolabel-compatible peptide–chelator conjugate architecture (non-radioactive chelator-enabled precursor; radiolabeling performed downstream by end user).
Explore related services: peptide imaging conjugates · non-drug peptide–ligand conjugates · site-specific peptide conjugation.
Chelator choice impacts coordination geometry, charge profile, labeling kinetics, and complex stability. We support representative macrocyclic chelators and can evaluate acyclic chelators or custom chelators provided by the client (project-dependent). Bio-Synthesis provides non-radioactive chelator–peptide conjugates intended for downstream radiolabeling workflows.
Not sure what to choose? Share your intended downstream radiometal and labeling conditions; we can recommend a compatible chelator handle and attachment strategy (project-dependent).
Macrocyclic chelators are frequently selected for their robust coordination and stability profiles. We can incorporate representative ligands using site-defined conjugation (project-dependent).
Acyclic chelators can offer faster labeling under some conditions and may be selected for specific workflow needs. We can evaluate client-specified acyclic ligands (project-dependent).
We can evaluate custom chelators (client-provided or literature-specified) for peptide conjugation feasibility. We will recommend an attachment handle (e.g., NHS-ester, maleimide, azide/alkyne, etc.) and spacer strategy if needed (project-dependent).
Confirm peptide sequence, chelator class, attachment site, and intended downstream imaging workflow.
If chelator is undecided, share your intended radiometal and labeling conditions (project-dependent).
Attach chelator using N-/C-terminus, single-Cys, or handle-enabled chemistries to reduce heterogeneity.
Spacer/linker strategies can be incorporated when needed (project-dependent).
Purify and confirm identity with fit-for-purpose analytical characterization.
Commonly includes HPLC/UPLC and LC-MS when feasible.
In addition to radiolabel-compatible peptide chelator conjugation, Bio-Synthesis supports a range of non-radioactive peptide conjugation services for imaging, targeting, and research workflows.
Fluorescent, biotinylated, and probe-labeled peptides designed for microscopy, binding assays, and imaging feasibility studies.
Explore peptide imaging conjugates →
Controlled, site-defined attachment strategies to minimize heterogeneity and preserve peptide activity.
View site-specific conjugation →
Non-drug peptide–ligand conjugates for targeting, binding studies, and early-stage research applications.
Learn about peptide–ligand conjugates →
No. Bio-Synthesis does not perform radiolabeling or handle radioactive materials. We provide non-radioactive peptide–chelator conjugates designed to be compatible with downstream radiolabeling workflows (project-dependent).
It is a non-radioactive peptide that has a chelator covalently attached so the end user can coordinate a radiometal later for imaging or tracer studies (project-dependent).
We support representative macrocyclic chelators and related ligands including DOTA, DO2A, DO3A, DOTP, TACN, NOTA, and TETA, and we can evaluate acyclic or custom chelators provided by the client (project-dependent).
Macrocyclic chelators often provide higher kinetic/thermodynamic stability, while some acyclic chelators may label quickly under mild conditions. Selection depends on the intended radiometal, labeling conditions, and use case (project-dependent).
Common options include N-terminus, C-terminus, a single engineered cysteine, or handle-enabled chemistries. Site-defined attachment helps minimize heterogeneity (project-dependent).
Yes. Spacers such as PEG or other linkers can be incorporated to reduce steric effects and tune hydrophilicity/handling (project-dependent).
Fit-for-purpose confirmation commonly includes chromatographic purity assessment (HPLC/UPLC) and mass confirmation (LC-MS when feasible), aligned to chelator properties and project needs (project-dependent).
Peptide sequence, preferred chelator (or target radiometal/labeling workflow), desired attachment site, target quantity, purity target, and any spacer/linker preferences.
Yes. Chelator–peptide conjugates are often used in feasibility studies, binding assays, and workflow development before any radiolabeling is performed (project-dependent).
Chelators can influence peptide behavior depending on size, charge, and attachment site. Site-defined conjugation and spacer strategies are used to minimize impact on peptide function (project-dependent).
Bio-Synthesis provides non-radioactive chelator–peptide conjugates; radiolabeling is performed by the end user.
Share your design details and intended imaging workflow. Our scientists will recommend a compatible chelator handle and a site-defined conjugation strategy (project-dependent).
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