Integrated peptide conjugation strategies
Glycopeptides, lipopeptides, peptide–oligonucleotide conjugates, and peptide–small molecule hybrids engineered for function, targeting, and delivery.
Bio-Synthesis provides hybrid and bioconjugate peptide synthesis services that integrate peptides with carbohydrates, lipids, oligonucleotides, and small molecules. These conjugates enable targeted delivery, multivalent recognition, assay development, and functional studies across immunology, diagnostics, and drug discovery.
Best-fit when you need
Control conjugation position to protect the binding face.
Tune length, flexibility, and optional cleavability.
Confirm composition and architecture for reproducibility.
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Use this table to map your project to the right hybrid format. For detailed options, see the service sections below.
Related service pages (internal links)
For full options, pricing drivers, and examples, visit the dedicated pages:
Glycopeptide synthesis attaches defined carbohydrate moieties to peptides to study glyco-epitopes, receptor recognition, and immune interactions. We can support site-specific glycosylation and linker strategies aligned to your assay or application.
Related: Glycopeptide synthesis service page.
Lipopeptide synthesis adds lipid moieties that can enhance membrane association, improve uptake, or provide adjuvant-like behavior. Lipid selection and placement strongly influence solubility and performance.
Related: Lipopeptide synthesis service page.
Peptide–oligonucleotide conjugates combine peptide targeting or cell-penetrating elements with DNA/RNA cargo. Linker chemistry and handle placement are critical for conjugation efficiency and biological performance.
Related: Peptide–oligonucleotide conjugates service page.
Peptide–small molecule hybrids link peptides to drugs, dyes, or probes to create targeted conjugates and functional tools. Linker design and attachment site selection are key to preserving activity.
Related: Peptide–small molecule hybrids service page.
Provide the peptide sequence, the desired glycan structure(s), the attachment site, any linker preference, and your target purity/scale. If you have assay constraints, include them so we can recommend accessibility and spacer options.
Often yes. Lipidation can increase hydrophobicity. Tell us your formulation constraints and we can recommend linker/sequence strategies and provide handling guidance for solubilization and storage.
Yes. Specify whether the peptide should attach to the 5′ or 3′ end (or internally), along with the oligo chemistry and any required modifications.
Choose cleavable linkers when payload release is part of the mechanism (e.g., intracellular release). Choose stable linkers when you need the conjugate to remain intact during binding or imaging.
Yes. We can incorporate orthogonal handles (azide/alkyne, cysteine, amines) to support modular assembly and site-specific conjugation—planned into the design.
Typical deliverables include purity reporting and LC–MS confirmation. For complex architectures, additional characterization (e.g., mapping or state verification) can be added to support reproducibility and downstream workflows.
Share your peptide sequence(s), conjugate type (glyco, lipo, oligo, small molecule), linker/handle requirements, and intended application. We’ll recommend practical specifications and a synthesis/QC plan aligned to your goals.
Tip: If the peptide is hydrophobic/long/cysteine-rich, include that context so we can route the request to the right synthesis strategy.
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