Positional scanning • Alanine & substitution libraries • Focused motif sets • High-throughput peptide panels • OEM/private-label supply • Backed by 45+ years of peptide manufacturing expertise
Combinatorial peptide libraries are designed collections of related peptides that systematically explore sequence diversity to map binding requirements, identify active motifs, or optimize lead candidates. Unlike single custom peptides, libraries must maintain coverage (the members you planned are actually present), consistency (members behave similarly lot-to-lot), and traceability (what was made and how it was verified).
Bio-Synthesis provides combinatorial peptide library synthesis using a manufacturing-first approach: library design review, sequence-aware synthesis strategy, purification planning, and QC aligned to screening versus validation. We support high-throughput peptide panels and OEM/private-label supply for qualified partners, backed by more than 45 years of peptide manufacturing expertise.
The goal is not just “a library once” — it’s repeatable supply as your program tightens specs.
Figure: Combinatorial peptide library synthesis concept illustrating split-and-mix diversity generation, library assembly, QC, and screening workflows
Related: Peptide Arrays, Peptide Libraries, Difficult Peptide Synthesis, Peptide Modifications.
Tools: Peptide Library Screening Tool
Fast-scanning matrix for buyers and partners. For design help, see library types and quote specs.
Need an addressable format for screening? Consider a peptide array approach in addition to soluble panels.
Certain residues and motifs couple less efficiently, skewing diversity or creating “dropouts.” We identify risk drivers early and adapt strategy to protect coverage.
Libraries can generate closely related impurities that confound screening. We align purification and analytics to your screen vs validation needs.
Programs often fail when the second run doesn’t match the first. We design workflows for repeatable manufacturing and documentation from day one.
If you already have a protein region of interest, we can help choose fragment length/offset to balance cost vs data resolution.
Built for speed and coverage.
Recommended for hit confirmation and SAR.
Built for repeat orders and consistency.
We do not publicly disclose partner relationships. OEM support is available under confidentiality for qualified vendors.
A combinatorial peptide library is a designed collection of related peptide sequences that systematically explores sequence diversity (e.g., substitutions at defined positions) to map binding/epitope requirements or optimize activity.
A peptide library refers to the collection design (diversity and composition). A peptide array is a physical format where many peptides are synthesized or printed in an addressable layout (e.g., membrane, slide, plate) for screening.
Yes. We support positional scanning, single‑position substitution sets (including alanine scanning), and focused motif libraries. Share your target motif and constraints and we’ll recommend a design.
Yes. We manufacture high-throughput peptide panels with consistent specifications and documentation to support screening and resupply.
Yes. OEM and private-label manufacturing support is available for qualified partners, including confidential supply and consistent specifications.
Many screens use fit‑for‑purpose purity targets to balance cost and speed, while confirmation sets typically use higher purity. Tell us your assay sensitivity and we’ll recommend targets for screening vs validation.
We apply sequence-aware synthesis strategy, monitor difficult motifs early, and align purification and QC to the library purpose. For high-risk motifs, we recommend design variants or process controls to maintain coverage.
Yes. We use aggregation-aware SPPS strategies and solubility-aware purification to improve recovery for difficult sequences within a library.
Typical deliverables include analytical HPLC/UPLC purity and LC–MS identity (as appropriate to the library type), plus a COA and chromatograms for representative or defined members. QC scope can be aligned to screening vs validation.
Provide the library design (positions varied, alphabet, length), number of members, quantity per member, target purity, and intended use (screening, mapping, validation). For panels, include naming/ID scheme and resupply needs.
Send your library design and intended assay workflow. We’ll recommend a synthesis + QC plan aligned to coverage, throughput, and resupply needs.
Confidential OEM/private-label supply is available for qualified partners. We can align SKUs/specs, documentation, and resupply planning.
High-throughput combinatorial peptide libraries and panels with manufacturing-first design, QC/COA, and OEM/private-label supply—backed by 45+ years of peptide manufacturing expertise.
Peptide Arrays Difficult Peptide Synthesis Peptide Modifications Peptide Libraries
Quote request form sales@biosyn.com +1-972-420-8505
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