Advanced modalities, targeting, conjugation, and engineered oligo formats—built for today’s therapeutic and translational programs.
Need standard services? See Custom Oligo Synthesis.
Bio-Synthesis supports specialty oligonucleotide programs from concept through development—combining custom synthesis, advanced chemistry, and precision conjugation to deliver complex, application-ready constructs. Whether you’re developing gene-silencing therapeutics, targeted delivery systems, or functional research tools, our platform is designed to help you move faster with reliable quality and flexible options.
Therapeutic modalities, targeting ligands, payloads, labels, and complex formats—configured to your application.
Tissue targeting, uptake/internalization, and release-focused strategies to improve functional performance.
Experienced chemistry + conjugation workflows that reduce trial-and-error and improve reproducibility.
Oligo platforms defined by mechanism of action—optimized for potency, stability, and PK.
Double-stranded RNA designs for RISC-mediated mRNA cleavage; options include stabilization chemistries and conjugation for delivery.
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Steric-blocking and RNase H-active gapmer architectures with backbone/sugar modifications and validated QC options.
Fully modified antisense constructs designed to modulate splicing without RNase H activation.
miRNA modulation formats for gain- or loss-of-function workflows; chemistry options tuned for stability and specificity.
Single-stranded DNA/RNA binders to proteins or small molecules; can be functionalized for targeting or imaging workflows.
Pharmacologically active payloads linked to oligonucleotides using controlled linker design, release engineering, and site-specific conjugation strategies.
Conjugation of pharmacologically active small-molecule payloads to oligos with architectures tuned for stability, activity, and intended mechanism.
Linker options to balance circulation stability and intracellular release (e.g., redox-, pH-, or enzyme-triggered cleavage).
Designs that control where/when payload is released to support functional delivery—often the key lever for potency and safety.
Click-ready handles and orthogonal ligations for site-specific, reproducible conjugate architectures and cleaner product profiles.
Targeting strategies that guide biodistribution and receptor engagement for improved tissue specificity.
ASGPR-mediated liver targeting formats compatible with siRNA and antisense workflows.
Folate receptor targeting for selective uptake; available with site-specific conjugation handles.
Custom small-molecule ligands and targeting motifs coupled to oligos for receptor-mediated delivery.
Conjugation formats that promote cell entry and improve intracellular delivery.
Cell-penetrating peptides and uptake-enhancing motifs to increase internalization across cell types.
Cholesterol and other lipid formats that enhance uptake and alter biodistribution and plasma exposure.
Chemistries and motifs designed to improve endosomal escape and cytosolic delivery for higher functional delivery to cytosol or nucleus.
Backbone and sugar chemistries that tune nuclease resistance, affinity, potency, and safety.
Neutral-backbone morpholino oligos designed for steric-blocking applications (e.g., splice switching) with enhanced nuclease resistance.
Peptide-like backbone oligos with high binding affinity and strong biological stability for specialized binding and assay applications.
Conformationally constrained sugar chemistries that increase duplex stability and affinity—commonly used to improve potency and specificity.
Internucleotide linkage chemistries (e.g., phosphorothioate, methylphosphonate and related options) to tune stability, PK, and activity.
2′-position sugar modifications (e.g., 2′-OMe, 2′-MOE, cEt, 2′-F) to enhance nuclease resistance and binding performance.
Expanded sugar-chemistry options such as cEt, ENA, TNA, SNA, UNA, and GNA to tune conformation, affinity, stability, and biological behavior for specialized applications.
Non-linear architectures and engineered topologies for multivalency, avidity, and modular function.
Covalently closed oligos that can enhance stability and enable specialized applications.
Multi-arm constructs from defined branching points for increased functional density.
Highly multivalent formats and multi-oligo assemblies for avidity and modular design.
Custom probe design and synthesis platforms supporting qPCR, FISH, signal amplification, spatial transcriptomics, and advanced molecular detection workflows.
End-to-end probe design, synthesis, labeling, and optimization services tailored to your assay platform.
Real-time PCR probe formats including hydrolysis-based systems for quantitative gene expression and diagnostic applications.
Hairpin-structured probes enabling sequence-specific fluorescence upon hybridization.
Dual-probe FRET systems designed for high-specificity detection in real-time PCR workflows.
Minor groove binder-enhanced probes that improve melting temperature and specificity in short probe designs.
Multiplexed Error-Robust Fluorescence In Situ Hybridization (MERFISH) probes for high-throughput spatial gene expression analysis.
Peptide nucleic acid-based FISH probes offering strong binding affinity and high specificity for cytogenetic applications.
Branched DNA amplification probe systems designed to enhance signal sensitivity without target amplification.
Chemically modified probe formats engineered to improve binding strength, specificity, and assay robustness.
Share your assay type (qPCR, FISH, MERFISH, bDNA), target(s), and preferred labels. We’ll recommend a practical design and quoting path.
Research and translational formats with built-in labels, handles, and affinity tags for workflows across discovery and development.
Fluorescent tags for tracking, uptake studies, and assay readouts.
Affinity handles for pull-down, capture, and binding workflows.
Azide/alkyne and other orthogonal handles for rapid post-synthesis functionalization.
Oligonucleotide imaging formats to support localization, biodistribution, and molecular detection workflows.
Probe designs for microscopy, flow, and imaging-based assays (including FRET formats where applicable).
NIR dye conjugates to support in vivo tracking and biodistribution studies.
Radiotracer designs for quantitative biodistribution and imaging workflows (where applicable).
Oligonucleotides conjugated to proteins and other macromolecules for targeting, diagnostics, and advanced molecular assemblies.
Antibody-mediated targeting formats (AOCs) for receptor-driven tissue delivery and specialized assay applications.
Site-specific conjugation of single-domain antibodies (VHH nanobodies) to oligonucleotides for compact, high-affinity targeting with improved tissue penetration and engineered specificity.
Covalent conjugation of engineered recombinant proteins to oligonucleotides for targeted delivery, functional modulation, or assay-driven applications with controlled orientation and linker design.
Enzyme-linked oligos for signal amplification, detection systems, or specialized functional assays.
Protein carriers to support exposure and delivery strategies; site-specific coupling options available.
Oligonucleotides conjugated to synthetic or natural polymers (e.g., PEG, PLGA, PEI, HPMA) to enhance stability, circulation time, controlled release, or nanostructure formation for advanced delivery applications.
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Share sequences, modality (siRNA/ASO/aptamer), targeting or conjugation needs, purity/scale requirements, and intended application. We’ll recommend a practical build + QC strategy and provide a quote.
Tip: If your project includes multiple sequences, provide a list plus shared specifications (purity, scale, modifications) to speed quoting.
No. This is a hub for advanced modalities, conjugation, and engineered formats. Standard DNA/RNA synthesis, modifications, and purification can remain on dedicated pages and be linked from relevant tiles.
Targeting focuses on where the oligo goes (tissue/receptor specificity). Uptake and internalization focus on how efficiently the oligo enters cells and becomes functionally available (often limited by endosomal escape).
Typically no. Lipid conjugates primarily enhance delivery or PK. “Drug conjugates” generally refer to pharmacologically active small-molecule payloads linked to the oligo.
Yes—this hub is designed as a gateway. Keep each tile summary short, and put detailed specifications, options, and expanded FAQs on the linked pages.
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