Preparative & analytical purification built around real impurity profiles — aligned with GLP / ISO 13485 quality systems (non-GMP).
Synthetic peptides often contain truncated sequences, deletion products, incomplete deprotection remnants, and modification byproducts. These can distort biological readouts and weaken reproducibility. Purification isolates the desired peptide fraction while controlling look-alike impurities that can co-elute or mimic activity.
Quality statement: Services are aligned with GLP / ISO 9001 & 13485 quality systems.
We treat purification as method development with a measurable goal: separate target from the most risk-relevant impurities, maintain yield, and provide verification data that matches your intended use.
Different methods separate peptides by different physical principles. The strongest results often come from orthogonal steps when a single mode cannot fully resolve the impurity set.
The primary workhorse for peptides, separating mainly by hydrophobicity. Selectivity is tuned by stationary phase choice, gradient shape, temperature, and mobile phase conditions.
Separates by charge at a chosen pH. Useful when target and impurities behave similarly in RP but differ in net charge.
Designed for polar analytes. Helps when peptides are too hydrophilic for strong RP retention or when RP selectivity is limited.
Separates by size rather than chemistry. Often used for desalting/buffer exchange and polishing, not primary look-alike impurity resolution.
If the main risk is “near neighbor” impurities that co-elute (or partially co-elute), forcing a single method can waste time and yield. A deliberate two-step approach typically wins.
If you don’t know the “right” purity target, share the downstream assay/application and we’ll recommend a fit-for-purpose specification.
We optimize separation against the impurities that matter most, not just “a peak.”
Chromatograms + MS confirmation + a COA that actually answers what you need.
Direct technical communication for fast troubleshooting and decision-making.
Deliverables can be tailored to your internal reporting requirements (templates, naming, traceability).
Services are aligned with GLP / ISO 13485 quality systems for regulated non-GMP needs.
If you’re unsure about purity requirements, tell us the assay or use-case. We’ll recommend a fit-for-purpose target and workflow.
Share your sequence and project constraints. Our scientists will recommend a purification strategy, expected selectivity risks, and an analytical plan aligned to your program requirements.
For faster routing, include: sequence, modifications, amount, and deadline in your email.
Trusted by biotech leaders worldwide for over 40+ years of delivering high quality, fast and scalable synthetic biology solutions.