Oligonucleotide Analytical Services

High-resolution oligonucleotide analysis, characterization, and QC testing for synthetic DNA and RNA.

High-resolution characterization and QC testing for synthetic DNA and RNA.

Overview

Comprehensive Oligonucleotide Characterization

Our oligonucleotide analytical services provide high-resolution characterization of synthetic DNA and RNA, combining orthogonal methods to evaluate molecular identity, purity, impurity profile, residual content, elemental composition, and performance-relevant attributes.

Oligonucleotide analytical services laboratory environment

Rather than relying on a single test result, we integrate mass spectrometry, chromatographic separation, physicochemical analysis, and microbiological assessment into a cohesive analytical workflow that supports clear interpretation and confident decision-making.

  • Identity: verify mass, structure, and sample integrity
  • Composition: assess water, sodium, residue, and residual solvents
  • Purity: resolve closely related oligonucleotide impurities
  • Performance: evaluate duplex formation and hybridization behavior
HR-LC-MS MALDI-TOF MS Integrated impurity insight Quantitative Duplex Analysis ICP-MS analysis Endotoxin Assay Bioburden

Analytical Services

Expand each analytical service to review scope, typical uses, and add a dedicated image for that method or workflow.

High-Resolution LC-MS (HR-LC-MS)

Accurate mass confirmation and structural characterization for oligonucleotides.

LC-MS Oligonucleotide Analysis

Combined chromatographic separation and mass confirmation for identity and impurity insight.

MALDI-TOF Mass Spectrometry

Rapid molecular weight confirmation for routine oligonucleotide QC.

RP-IP HPLC

High-resolution purity analysis and impurity profiling.

Ion-Pairing Chromatography

Complementary separation for closely related oligonucleotide species.

UV-Vis Spectroscopy

Concentration measurement and analytical normalization.

Quantitative Duplex Analysis

Assessment of hybridization and duplex formation.

ICP-MS Analysis

Elemental and sodium content analysis.

Karl Fischer Analysis

Water content determination for stability and formulation.

Residual Solvent GC

Detection of residual solvents such as acetonitrile.

Residue on Ignition

Assessment of inorganic residue and impurities.

Bioburden Assay

Microbial quality testing for sensitive applications

Oligonucleotide Modalities & Applications

Supported oligonucleotide types

  • Antisense oligonucleotides (ASOs)
  • siRNA and duplex RNA systems
  • Chemically modified oligonucleotides
  • Conjugated and labeled oligonucleotides
  • Synthetic DNA and RNA for advanced research programs

Why this matters for SEO and conversion

Search engines reward pages that clearly connect services to real applications. Including modality language such as ASO analysis, siRNA characterization, and modified oligonucleotide QC testing helps this page rank for higher-intent searches while remaining relevant to technical buyers.

  • Improves topical relevance for nucleic acid analytical services
  • Captures long-tail search intent without keyword stuffing
  • Strengthens fit between search query and page content

Deliverables & Reporting

Typical deliverables

  • High-resolution chromatographic and spectral datasets
  • Integrated oligonucleotide analytical reports
  • Purity, identity, residual, and composition summaries
  • Quantitative analysis with interpretation
  • Certificate of Analysis (COA)

This structure supports both technical review and commercial decision-making by presenting clear, interpretable, and actionable data.

Integrated analytical insight

  • Structural, organic impurity, inorganic impurity, and residual solvent coverage
  • Orthogonal confirmation across analytical platforms
  • Decision-ready reporting for research and development teams
  • Focused oligonucleotide expertise with high-resolution methods

This combination of depth, precision, and interpretability helps position the page strongly for searches related to oligonucleotide analysis services and oligonucleotide characterization.

Request a Quote

What to provide

  • Oligonucleotide sequence and modifications
  • Sample format, concentration, and matrix details
  • Requested analytical services or target data objectives
  • Known concerns related to purity, residuals, or composition
  • Reporting expectations and timeline

Share your project details and analytical goals. Your team can recommend a fit-for-purpose oligonucleotide analysis panel aligned to your timeline and reporting needs.

Fastest path

Why Choose Bio-Synthesis

Trusted by biotech leaders worldwide for over 45+ years of delivering high quality, fast and scalable synthetic biology solutions.