Therapeutic oligonucleotide development requires precise control over molecular architecture, backbone chemistry, stereochemistry, and conjugation strategy. Bio-Synthesis supports pharmaceutical and biotechnology programs with advanced oligonucleotide platforms built for structural precision, reproducibility, and scalable manufacturing.
Our capabilities extend beyond standard oligo synthesis to include large-scale production, stereodefined phosphorothioate control (Rp/Sp), and integration of diverse backbone chemistries including PS, PS2, PN, and PACE-type systems. We routinely support non-canonical and complex architectures such as asymmetric duplexes, mixed backbone designs, extended constructs, and conjugation-enabled therapeutic oligos.
siRNA
ASO
aptamers
SSO
miRNA mimics
bioconjugation
ISO 9001:2015 / ISO 13485:2016
45+ Years of Expertise
U.S. Facilities - Texas
Bench to preclinical
This overview page highlights the major therapeutic oligonucleotide modalities we support, including siRNA synthesis, antisense oligonucleotide (ASO) services, aptamers, splice-switching oligonucleotides (SSO), miRNA mimics, and therapeutic oligo bioconjugation for delivery and targeting.
Therapeutic oligonucleotide platform
Build • Control • Scale
Advanced therapeutic oligonucleotide design with full control over architecture, chemistry, stereochemistry, and conjugation — executed with reproducibility across development and manufacturing scale.
Scale
1000 g+
Large-scale program support
Stereochemistry
Rp / Sp
Stereodefined PS capable
Backbone
PS • PN • PACE
Advanced linkage systems
Design
Flexible
Non-canonical & complex architectures