Therapeutic Oligonucleotide Services

Advanced therapeutic oligonucleotide platform support spanning siRNA synthesis, antisense oligonucleotides (ASO), aptamers, splice-switching oligonucleotides (SSO), miRNA mimics, and bioconjugation-enabled architectures for research, translational, and preclinical programs.

Overview

Therapeutic oligonucleotide development requires precise control over molecular architecture, backbone chemistry, stereochemistry, and conjugation strategy. Bio-Synthesis supports pharmaceutical and biotechnology programs with advanced oligonucleotide platforms built for structural precision, reproducibility, and scalable manufacturing.

Our capabilities extend beyond standard oligo synthesis to include large-scale production, stereodefined phosphorothioate control (Rp/Sp), and integration of diverse backbone chemistries including PS, PS2, PN, and PACE-type systems. We routinely support non-canonical and complex architectures such as asymmetric duplexes, mixed backbone designs, extended constructs, and conjugation-enabled therapeutic oligos.

siRNA ASO aptamers SSO miRNA mimics bioconjugation ISO 9001:2015 / ISO 13485:2016 45+ Years of Expertise U.S. Facilities - Texas Bench to preclinical

This overview page highlights the major therapeutic oligonucleotide modalities we support, including siRNA synthesis, antisense oligonucleotide (ASO) services, aptamers, splice-switching oligonucleotides (SSO), miRNA mimics, and therapeutic oligo bioconjugation for delivery and targeting.

Therapeutic oligonucleotide platform

Build • Control • Scale

Advanced therapeutic oligonucleotide design with full control over architecture, chemistry, stereochemistry, and conjugation — executed with reproducibility across development and manufacturing scale.

Scale

1000 g+

Large-scale program support

Stereochemistry

Rp / Sp

Stereodefined PS capable

Backbone

PS • PN • PACE

Advanced linkage systems

Design

Flexible

Non-canonical & complex architectures

Therapeutic Oligonucleotide Modalities and Enabling Technologies

siRNA duplex structure and RNA interference mechanism illustration

siRNA Synthesis

Custom siRNA synthesis support for RNA interference workflows, target knockdown studies, and translational development programs.

  • Sense / antisense duplex design
  • Modified siRNA options
  • Research to preclinical support
Antisense oligonucleotide binding to target RNA illustration

Antisense Oligonucleotides (ASO)

Antisense oligonucleotide (ASO) services for target-specific RNA modulation, knockdown, steric blocking, and therapeutic oligonucleotide evaluation.

  • Gapmer and steric-blocking concepts
  • Backbone and sugar modification options
  • Targeted RNA regulation workflows
Aptamer folding and target protein binding illustration

Aptamers

Aptamer services for target recognition, binding studies, and therapeutic or diagnostic development concepts.

  • Binding-oriented oligo architectures
  • Stability and modification support
  • Recognition-based development programs
Splice-switching oligonucleotide modifying RNA splicing illustration

Splice-Switching Oligonucleotides (SSO)

Splice-switching oligonucleotide (SSO) services for exon-skipping, splice redirection, and steric intervention strategies in RNA processing workflows.

  • Splice-modulating oligo design
  • Steric-blocking architectures
  • Application-driven modification support
miRNA mimic duplex regulating gene expression illustration

miRNA Mimics

miRNA mimic synthesis and related service support for regulatory RNA studies, pathway modulation, and therapeutic mechanism evaluation.

  • Double-stranded mimic constructs
  • Functional pathway study support
  • Research and translational workflows
Therapeutic oligonucleotide conjugated to ligand or delivery system illustration

Therapeutic Oligo Bioconjugation

Therapeutic oligo bioconjugation strategies to enhance delivery, targeting, and pharmacological performance, including ligand, peptide, and polymer attachments.

  • Ligand and receptor-targeting conjugates
  • Peptide and polymer conjugation
  • Delivery-enhancing architectures

Program Workflow

Therapeutic oligonucleotide program workflow showing define goal, select class, configure design, and advance program
A typical therapeutic oligonucleotide program moves from target and mechanism definition to oligo class selection, sequence and chemistry optimization, and downstream research-to-preclinical advancement.

Therapeutic Oligonucleotide Modality Comparison

This overview table helps distinguish the major therapeutic oligonucleotide classes by biological mechanism and typical development focus.

Modality Primary mechanism Typical focus Representative use
siRNA RNA interference-mediated knockdown Gene silencing Target transcript reduction
ASO RNA binding for degradation or steric blocking Target-specific RNA modulation Knockdown or functional blocking
Aptamers Direct target binding and recognition Binding-driven targeting Recognition and ligand-like function
SSO Splice redirection by steric intervention Splicing modulation Exon skipping or splice correction
miRNA mimics Regulatory RNA replacement or augmentation Pathway modulation Restoring or enhancing miRNA function
Bioconjugation Delivery, targeting, or pharmacology enhancement Enabling technology Ligand, peptide, or polymer conjugation

Why This Matters

Clarifies Strategy

This kind of overview page helps users identify the correct oligonucleotide class before moving into deeper technical detail.

Supports Internal Linking

Each therapeutic category can link to a dedicated technical page without overloading the overview page itself.

Improves Program Readiness

Grouping related service areas in one hub helps users understand how different therapeutic oligo strategies relate to one another.

FAQ

What therapeutic oligonucleotide modalities do you support?

We support multiple therapeutic oligonucleotide categories including siRNA, antisense oligonucleotides (ASO), aptamers, splice-switching oligonucleotides (SSO), miRNA mimics, and therapeutic oligo bioconjugation strategies.

How do I know which oligo class is right for my program?

The correct modality depends on the intended biological mechanism, such as RNA knockdown, splice redirection, pathway modulation, or target binding. This overview page helps users identify the most relevant service area before moving into the detailed technical page.

Can you support modified therapeutic oligonucleotides?

Yes. Therapeutic oligo programs often require backbone, sugar, end-group, or conjugation-based modifications depending on stability, delivery, and performance goals.

Do you support research-only or more advanced development programs?

These services are relevant across research, translational, and preclinical workflows. Program scope can range from discovery-stage screening to more structured development support depending on the oligonucleotide class.

Can therapeutic oligonucleotides be linked to delivery or conjugation strategies?

Yes. Depending on the modality, therapeutic oligos may be paired with ligand, peptide, polymer, or other bioconjugation approaches to support delivery, targeting, or pharmacological performance.

What information helps with quoting?

For the fastest quote, share the therapeutic oligo type, target or mechanism, preferred chemistry or modification needs, intended application, and the current stage of your program.

Contact & Quote Request

For the fastest quote, share the therapeutic oligo type, target or mechanism, preferred chemistry or modification needs, and the stage of your program.

What to include

  • Oligo class or target mechanism
  • Research, translational, or preclinical stage
  • Preferred chemistry or architecture
  • Scale and downstream application

Fastest path

Why Choose Bio-Synthesis

Trusted by biotech leaders worldwide for over 45+ years of delivering high quality, fast and scalable synthetic biology solutions.