This is peptide is selected from amino acids 58 to 66 fragment of the immature laminin receptor protein (iLRP). The oncofetal antigen immature laminin receptor protein (OFA-iLRP) is a highly conserved protein that is preferentially expressed in fetal tissues and in many types of cancer, including hematopoietic malignancies, whereas OFA-iLRP is not detectable on healthy differentiated adult cells.The oncofetal antigen (OFA)-iLRP-specific CTLs generated with autologous OFA-iLRP RNA-transfected dendritic cells contain T lymphocytes capable of recognizing this iLRP1 peptide as demonstrated by its potential to kill T2 cells loaded with this peptide.
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